OBJECTIVE: The objective of this study was to systematically review patient-reported outcomes of long-term macrolide therapy, compared with any other treatment, for adults with chronic rhinosinusitis. DATA SOURCES: EMBASE and PubMed databases were searched in October 2011. REVIEW METHODS: A total of 1216 citations were screened initially by a single author, 23 full-text manuscripts were evaluated by 2 authors using structured data abstraction forms to assess for inclusion criteria and study quality, and 3 studies were included in the final review. RESULTS: This review finds that 3 prospective clinical studies have evaluated the effect of macrolide therapy for chronic rhinosinusitis. Based on the limited data, there is limited scientific evidence to support the use of long-term macrolide therapy for chronic rhinosinusitis. CONCLUSION: Further clinical research is needed to determine whether there may be a subgroup effect based on the underlying inflammatory disease process.
OBJECTIVE: The objective of this study was to systematically review patient-reported outcomes of long-term macrolide therapy, compared with any other treatment, for adults with chronic rhinosinusitis. DATA SOURCES: EMBASE and PubMed databases were searched in October 2011. REVIEW METHODS: A total of 1216 citations were screened initially by a single author, 23 full-text manuscripts were evaluated by 2 authors using structured data abstraction forms to assess for inclusion criteria and study quality, and 3 studies were included in the final review. RESULTS: This review finds that 3 prospective clinical studies have evaluated the effect of macrolide therapy for chronic rhinosinusitis. Based on the limited data, there is limited scientific evidence to support the use of long-term macrolide therapy for chronic rhinosinusitis. CONCLUSION: Further clinical research is needed to determine whether there may be a subgroup effect based on the underlying inflammatory disease process.
Authors: Richard M Rosenfeld; David Andes; Neil Bhattacharyya; Dickson Cheung; Steven Eisenberg; Theodore G Ganiats; Andrea Gelzer; Daniel Hamilos; Richard C Haydon; Patricia A Hudgins; Stacie Jones; Helene J Krouse; Lawrence H Lee; Martin C Mahoney; Bradley F Marple; Col John P Mitchell; Robert Nathan; Richard N Shiffman; Timothy L Smith; David L Witsell Journal: Otolaryngol Head Neck Surg Date: 2007-09 Impact factor: 3.497
Authors: Carl Philpott; Steffi le Conte; David Beard; Jonathan Cook; William Sones; Steve Morris; Caroline S Clarke; Mike Thomas; Paul Little; Jane Vennik; Valerie Lund; Helen Blackshaw; Anne Schilder; Stephen Durham; Spiros Denaxas; James Carpenter; James Boardman; Claire Hopkins Journal: Trials Date: 2019-04-29 Impact factor: 2.279
Authors: Karen Head; Lee Yee Chong; Patorn Piromchai; Claire Hopkins; Carl Philpott; Anne G M Schilder; Martin J Burton Journal: Cochrane Database Syst Rev Date: 2016-04-26
Authors: Judd H Fastenberg; Wayne D Hsueh; Ali Mustafa; Nadeem A Akbar; Waleed M Abuzeid Journal: World J Otorhinolaryngol Head Neck Surg Date: 2016-05-05