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Literature DB >> 23313270

Tricycloalternarenes F-H: three new mixed terpenoids produced by an endolichenic fungus Ulocladium sp. using OSMAC method.

Quan-Xin Wang¹, Li Bao, Xiao-Li Yang, Hui Guo, Biao Ren, Liang-Dong Guo, Fu-Hang Song, Wen-Zhao Wang, Hong-Wei Liu, Li-Xin Zhang.

Abstract

Three new mixed terpenoids, tricycloalternarenes (TCAs) F-H (1-3), together with ten known tricycloalternarenes (4-13), were isolated from the Czapek's culture of an endophytic fungus Ulocladium sp. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data. TCA 1b (5) showed weak activity against the Bacille Calmette-Guerin strain with the MIC of 125μg/mL. TCA 9b (10) exhibited strong cytotoxic activity against Hela cell line with IC50 of 8.58μM.

Entities: Chemical Gene

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Year: 2013 PMID： 23313270 DOI： 10.1016/j.fitote.2012.12.029

Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882

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Cited

8 in total

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Journal: Arch Microbiol Date: 2021-03-29 Impact factor: 2.552

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Journal: J Nat Prod Date: 2016-11-11 Impact factor: 4.050

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Journal: Mar Drugs Date: 2015-01-07 Impact factor: 5.118

Review 4. Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review.

Authors: Rui Pan; Xuelian Bai; Jianwei Chen; Huawei Zhang; Hong Wang
Journal: Front Microbiol Date: 2019-02-26 Impact factor: 5.640

5. Endolichenic Fungal Community Analysis by Pure Culture Isolation and Metabarcoding: A Case Study of Parmotrema tinctorum.

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Journal: Mycobiology Date: 2022-02-24 Impact factor: 1.858

Tricycloalternarenes F-H: three new mixed terpenoids produced by an endolichenic fungus Ulocladium sp. using OSMAC method.

1. Induction of metabolic variability of the endophytic fungus Xylaria sp. by OSMAC approach and experimental design.

2. Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols.

3. New meroterpenoids from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius.

Review 4. Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review.

5. Endolichenic Fungal Community Analysis by Pure Culture Isolation and Metabarcoding: A Case Study of Parmotrema tinctorum.

Review 6. Antimicrobial Compounds Isolated from Endolichenic Fungi: A Review.

7. Cytotoxic Tricycloalternarene Compounds from Endophyte Alternaria sp. W-1 Associated with Laminaria japonica.

8. Tricycloalternarene Analogs from a Symbiotic Fungus Aspergillus sp. D and Their Antimicrobial and Cytotoxic Effects.