Literature DB >> 23312906

HDAC1-mSin3a-NCOR1, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a regulate the NY-ESO1 gene expression.

Pierre-François Cartron1, Christophe Blanquart, Eric Hervouet, Marc Gregoire, François M Vallette.   

Abstract

The NY-ESO1 gene is a cancer/testis antigen considered to be suitable target for the immunotherapy of human malignancies. Despite the identification of the epigenetical silencing of the NY-ESO1 gene in a large variety of tumors, the molecular mechanism involved in this phenomenon is not fully elucidated. In two non epithelial cancers (glioma and mesothelioma), we found that the epigenetic regulation of the NY-ESO1 gene requires the sequential recruitment of the HDAC1-mSin3a-NCOR, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a complexes. Thus, our data illustrate the orchestration of a sequential epigenetic mechanism including the histone deacetylation and methylation, and the DNA methylation processes.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 23312906      PMCID： PMC5528493          DOI： 10.1016/j.molonc.2012.11.004

Source DB:  PubMed          Journal:  Mol Oncol        ISSN： 1574-7891            Impact factor:   6.603


  27 in total

1.  UHRF1 plays a role in maintaining DNA methylation in mammalian cells.

Authors:  Magnolia Bostick; Jong Kyong Kim; Pierre-Olivier Estève; Amander Clark; Sriharsa Pradhan; Steven E Jacobsen
Journal:  Science       Date:  2007-08-02       Impact factor: 47.728

2.  Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.

Authors:  Eric Hervouet; François M Vallette; Pierre-François Cartron
Journal:  Epigenetics       Date:  2009-10-21       Impact factor: 4.528

3.  Vaccination with epigenetically treated mesothelioma cells induces immunisation and blocks tumour growth.

Authors:  Flora Guillot; Benoît Boutin; Christophe Blanquart; Jean-François Fonteneau; Myriam Robard; Marc Grégoire; Daniel Pouliquen
Journal:  Vaccine       Date:  2011-05-25       Impact factor: 3.641

4.  Cancer/testis antigen expression in human mesenchymal stem cells: down-regulation of SSX impairs cell migration and matrix metalloproteinase 2 expression.

Authors:  Garth Cronwright; Katarina Le Blanc; Cecilia Götherström; Pádraig Darcy; Monika Ehnman; Bertha Brodin
Journal:  Cancer Res       Date:  2005-03-15       Impact factor: 12.701

5.  Dnmt1/Transcription factor interactions: an alternative mechanism of DNA methylation inheritance.

Authors:  Eric Hervouet; François M Vallette; Pierre-François Cartron
Journal:  Genes Cancer       Date:  2010-05

6.  The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA.

Authors:  Jafar Sharif; Masahiro Muto; Shin-ichiro Takebayashi; Isao Suetake; Akihiro Iwamatsu; Takaho A Endo; Jun Shinga; Yoko Mizutani-Koseki; Tetsuro Toyoda; Kunihiro Okamura; Shoji Tajima; Kohzoh Mitsuya; Masaki Okano; Haruhiko Koseki
Journal:  Nature       Date:  2007-11-11       Impact factor: 49.962

7.  MGMT gene silencing and benefit from temozolomide in glioblastoma.

Authors:  Monika E Hegi; Annie-Claire Diserens; Thierry Gorlia; Marie-France Hamou; Nicolas de Tribolet; Michael Weller; Johan M Kros; Johannes A Hainfellner; Warren Mason; Luigi Mariani; Jacoline E C Bromberg; Peter Hau; René O Mirimanoff; J Gregory Cairncross; Robert C Janzer; Roger Stupp
Journal:  N Engl J Med       Date:  2005-03-10       Impact factor: 91.245

8.  HDAC1-mSin3a-NCOR1, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a regulate the NY-ESO1 gene expression.

Authors:  Pierre-François Cartron; Christophe Blanquart; Eric Hervouet; Marc Gregoire; François M Vallette
Journal:  Mol Oncol       Date:  2012-12-21       Impact factor: 6.603

Review 9.  A potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy.

Authors:  Adam R Karpf
Journal:  Epigenetics       Date:  2006 Jul-Sep       Impact factor: 4.528

Review 10.  Epigenetic targets for immune intervention in human malignancies.

Authors:  Michele Maio; Sandra Coral; Elisabetta Fratta; Maresa Altomonte; Luca Sigalotti
Journal:  Oncogene       Date:  2003-09-29       Impact factor: 9.867
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  22 in total

Review 1.  Targeting the epigenome in malignant pleural mesothelioma.

Authors:  Kaitlin C McLoughlin; Andrew S Kaufman; David S Schrump
Journal:  Transl Lung Cancer Res       Date:  2017-06

2.  Perinatal α-linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse offspring.

Authors:  Fuli He; Daniel S Lupu; Mihai D Niculescu
Journal:  Int J Dev Neurosci       Date:  2014-05-24       Impact factor: 2.457

3.  UHRF1 promotes renal cell carcinoma progression through epigenetic regulation of TXNIP.

Authors:  Dian Jiao; Yi Huan; Jia Zheng; Ming Wei; Guoxu Zheng; Donghui Han; Jieheng Wu; Wenjin Xi; Feilong Wei; An-Gang Yang; Weijun Qin; He Wang; Weihong Wen
Journal:  Oncogene       Date:  2019-05-01       Impact factor: 9.867

4.  HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation.

Authors:  Dhanusha A Nalawansha; Inosha D Gomes; Magdalene K Wambua; Mary Kay H Pflum
Journal:  Cell Chem Biol       Date:  2017-04-06       Impact factor: 8.116

5.  Epigenetic and Transcriptomic Programming of HSC Quiescence Signaling in Large for Gestational Age Neonates.

Authors:  Alexandre Pelletier; Arnaud Carrier; Yongmei Zhao; Mickaël Canouil; Mehdi Derhourhi; Emmanuelle Durand; Lionel Berberian-Ferrato; John Greally; Francine Hughes; Philippe Froguel; Amélie Bonnefond; Fabien Delahaye
Journal:  Int J Mol Sci       Date:  2022-06-30       Impact factor: 6.208

6.  HDAC1-mSin3a-NCOR1, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a regulate the NY-ESO1 gene expression.

Authors:  Pierre-François Cartron; Christophe Blanquart; Eric Hervouet; Marc Gregoire; François M Vallette
Journal:  Mol Oncol       Date:  2012-12-21       Impact factor: 6.603

7.  Combined Analysis of RNA Sequence and Microarray Data Reveals a Competing Endogenous RNA Network as Novel Prognostic Markers in Malignant Pleural Mesothelioma.

Authors:  Weicheng Duan; Kang Wang; Yijie Duan; Xiuyi Chen; Xufeng Chu; Ping Hu; Bo Xiong
Journal:  Front Oncol       Date:  2021-04-23       Impact factor: 6.244

Review 8.  Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex.

Authors:  Omeima Abdullah; Ziad Omran; Salman Hosawi; Ali Hamiche; Christian Bronner; Mahmoud Alhosin
Journal:  Genes (Basel)       Date:  2021-04-22       Impact factor: 4.096

9.  Identification of a large protein network involved in epigenetic transmission in replicating DNA of embryonic stem cells.

Authors:  Sergi Aranda; Dorothea Rutishauser; Patrik Ernfors
Journal:  Nucleic Acids Res       Date:  2014-05-22       Impact factor: 16.971

10.  Exemestane blocks mesothelioma growth through downregulation of cAMP, pCREB and CD44 implicating new treatment option in patients affected by this disease.

Authors:  Barbara Nuvoli; Sabrina Germoni; Carlotta Morosetti; Raffaela Santoro; Giancarlo Cortese; Serena Masi; Iole Cordone; Rossella Galati
Journal:  Mol Cancer       Date:  2014-03-21       Impact factor: 27.401
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