Literature DB >> 23307865

Alternative lengthening of telomeres in normal mammalian somatic cells.

Axel A Neumann1, Catherine M Watson, Jane R Noble, Hilda A Pickett, Patrick P L Tam, Roger R Reddel.   

Abstract

Some cancers use alternative lengthening of telomeres (ALT), a mechanism whereby new telomeric DNA is synthesized from a DNA template. To determine whether normal mammalian tissues have ALT activity, we generated a mouse strain containing a DNA tag in a single telomere. We found that the tagged telomere was copied by other telomeres in somatic tissues but not the germline. The tagged telomere was also copied by other telomeres when introgressed into CAST/EiJ mice, which have telomeres more similar in length to those of humans. We conclude that ALT activity occurs in normal mouse somatic tissues.

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Year:  2013        PMID： 23307865      PMCID： PMC3553280          DOI： 10.1101/gad.205062.112

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  27 in total

1.  Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA.

Authors:  H Niida; Y Shinkai; M P Hande; T Matsumoto; S Takehara; M Tachibana; M Oshimura; P M Lansdorp; Y Furuichi
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

2.  Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells.

Authors:  K Perrem; L M Colgin; A A Neumann; T R Yeager; R R Reddel
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

3.  Universal PCR genotyping assay that achieves single copy sensitivity with any primer pair.

Authors:  Jennifer L Stratman; Wayne M Barnes; Theodore C Simon
Journal:  Transgenic Res       Date:  2003-08       Impact factor: 2.788

Review 4.  T-loops and the origin of telomeres.

Authors:  Titia de Lange
Journal:  Nat Rev Mol Cell Biol       Date:  2004-04       Impact factor: 94.444

5.  Conservation of the human telomere sequence (TTAGGG)n among vertebrates.

Authors:  J Meyne; R L Ratliff; R K Moyzis
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

6.  A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.

Authors:  C W Greider; E H Blackburn
Journal:  Nature       Date:  1989-01-26       Impact factor: 49.962

7.  Telomere maintenance by recombination in human cells.

Authors:  M A Dunham; A A Neumann; C L Fasching; R R Reddel
Journal:  Nat Genet       Date:  2000-12       Impact factor: 38.330

8.  Human telomerase can immortalize Indian muntjac cells.

Authors:  Ying Zou; Xiaoming Yi; Woodring E Wright; Jerry W Shay
Journal:  Exp Cell Res       Date:  2002-11-15       Impact factor: 3.905

9.  Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression.

Authors:  Sandy Chang; Christine M Khoo; Maria L Naylor; Richard S Maser; Ronald A DePinho
Journal:  Genes Dev       Date:  2003-01-01       Impact factor: 11.361

10.  Telomere dynamics in an immortal human cell line.

Authors:  J P Murnane; L Sabatier; B A Marder; W F Morgan
Journal:  EMBO J       Date:  1994-10-17       Impact factor: 11.598
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  59 in total

Review 1.  Molecular mechanisms of activity and derepression of alternative lengthening of telomeres.

Authors:  Hilda A Pickett; Roger R Reddel
Journal:  Nat Struct Mol Biol       Date:  2015-11-04       Impact factor: 15.369

2.  Inter-telomeric recombination is present in telomerase-positive human cells.

Authors:  Margit Dlaska; Patrick Schöffski; Oliver E Bechter
Journal:  Cell Cycle       Date:  2013-06-06       Impact factor: 4.534

Review 3.  Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training.

Authors:  Joshua Denham; Brendan J O'Brien; Fadi J Charchar
Journal:  Sports Med       Date:  2016-09       Impact factor: 11.136

Review 4.  How homologous recombination maintains telomere integrity.

Authors:  Eliana M C Tacconi; Madalena Tarsounas
Journal:  Chromosoma       Date:  2014-11-29       Impact factor: 4.316

Review 5.  Break induced replication in eukaryotes: mechanisms, functions, and consequences.

Authors:  Cynthia J Sakofsky; Anna Malkova
Journal:  Crit Rev Biochem Mol Biol       Date:  2017-04-21       Impact factor: 8.250

6.  CD4+ memory T cells infected with latent HIV-1 are susceptible to drugs targeting telomeres.

Authors:  Dorota Piekna-Przybylska; Sanjay B Maggirwar
Journal:  Cell Cycle       Date:  2018-09-20       Impact factor: 4.534

7.  Recombinogenic telomeres in diploid Sorex granarius (Soricidae, Eulipotyphla) fibroblast cells.

Authors:  N S Zhdanova; I Draskovic; J M Minina; T V Karamysheva; C L Novo; W-Y Liu; R M Porreca; A Gibaud; M E Zvereva; D A Skvortsov; N B Rubtsov; A Londoño-Vallejo
Journal:  Mol Cell Biol       Date:  2014-05-19       Impact factor: 4.272

8.  Always a price to pay: hibernation at low temperatures comes with a trade-off between energy savings and telomere damage.

Authors:  Julia Nowack; Iris Tarmann; Franz Hoelzl; Steve Smith; Sylvain Giroud; Thomas Ruf
Journal:  Biol Lett       Date:  2019-10-02       Impact factor: 3.703

Review 9.  Break-induced replication: functions and molecular mechanism.

Authors:  Anna Malkova; Grzegorz Ira
Journal:  Curr Opin Genet Dev       Date:  2013-06-18       Impact factor: 5.578

10.  The emergence of the conserved AAA+ ATPases Pontin and Reptin on the signaling landscape.

Authors:  Jean Rosenbaum; Sung Hee Baek; Anindya Dutta; Walid A Houry; Otmar Huber; Ted R Hupp; Pedro M Matias
Journal:  Sci Signal       Date:  2013-03-12       Impact factor: 8.192
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