Mashhoor F Al Fayez1. 1. The Eye and Laser Centre and Department of Ophthalmology, King Abdulaziz University Medical School, Jeddah, Saudi Arabia. malfayez@kau.edu.sa
Abstract
OBJECTIVE: To compare the safety and efficacy of limbal-conjunctival vs conjunctival autograft transplant for treating recurrent pterygia. METHODS: In a randomized, prospective, parallel-group clinical trial, 224 patients with advanced recurrent pterygia underwent free conjunctival autograft transplant (112 eyes) or limbal-conjunctival autograft transplant (112 eyes). Two hundred five patients completed the follow-up (100 eyes from the conjunctival autograft group and 105 eyes from the limbal-conjunctival autograft group). MAIN OUTCOME MEASURES: Recurrence of pterygium, with complications as the secondary outcome measure (ie, signs of limbal stem cell deficiency). RESULTS: With a mean follow-up of 62 (range, 36-96) months, 10 patients (10.0%) in the conjunctival autograft group and 1 patient (1.0%) in the limbal-conjunctival autograft group developed recurrence. No signs of limbal stem cell deficiency were observed during follow-up. CONCLUSION: Limbal-conjunctival transplant is safe and more effective than free conjunctival transplant in preventing recurrence after excision of recurrent pterygia (P = .004). APPLICATION TO CLINICAL PRACTICE: Limbal-conjunctival autografts could be a favored option for managing advanced recurrent pterygia in young high-risk patients.
RCT Entities:
OBJECTIVE: To compare the safety and efficacy of limbal-conjunctival vs conjunctival autograft transplant for treating recurrent pterygia. METHODS: In a randomized, prospective, parallel-group clinical trial, 224 patients with advanced recurrent pterygia underwent free conjunctival autograft transplant (112 eyes) or limbal-conjunctival autograft transplant (112 eyes). Two hundred five patients completed the follow-up (100 eyes from the conjunctival autograft group and 105 eyes from the limbal-conjunctival autograft group). MAIN OUTCOME MEASURES: Recurrence of pterygium, with complications as the secondary outcome measure (ie, signs of limbal stem cell deficiency). RESULTS: With a mean follow-up of 62 (range, 36-96) months, 10 patients (10.0%) in the conjunctival autograft group and 1 patient (1.0%) in the limbal-conjunctival autograft group developed recurrence. No signs of limbal stem cell deficiency were observed during follow-up. CONCLUSION: Limbal-conjunctival transplant is safe and more effective than free conjunctival transplant in preventing recurrence after excision of recurrent pterygia (P = .004). APPLICATION TO CLINICAL PRACTICE: Limbal-conjunctival autografts could be a favored option for managing advanced recurrent pterygia in young high-risk patients.
Authors: Tommy C Y Chan; Raymond L M Wong; Emmy Y M Li; Hunter K L Yuen; Emily F Y Yeung; Vishal Jhanji; Ian Y H Wong Journal: J Ophthalmol Date: 2015-02-25 Impact factor: 1.909