Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.

Literature DB >> 23305922

Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.

Isaac Zentner¹, Luz-Jeannette Sierra, Lina Maciunas, Andrei Vinnik, Peter Fedichev, Marie K Mankowski, Roger G Ptak, Julio Martín-García, Simon Cocklin.

Abstract

Due to the emergence of drug-resistant strains and the cumulative toxicities associated with current therapies, demand remains for new inhibitors of HIV-1 replication. The HIV-1 matrix (MA) protein is an essential viral component with established roles in the assembly of the virus. Using virtual and surface plasmon resonance (SPR)-based screening, we describe the identification of the first small molecule to bind to the HIV-1 MA protein and to possess broad range anti-HIV properties.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 23305922 PMCID： PMC3557583 DOI： 10.1016/j.bmcl.2012.11.041

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

56 in total

1. Molecular modelling study of HIV p17gag (MA) protein shell utilising data from electron microscopy and X-ray crystallography.

Authors: M J Forster; B Mulloy; M V Nermut
Journal: J Mol Biol Date: 2000-05-19 Impact factor: 5.469

2. Entropic switch regulates myristate exposure in the HIV-1 matrix protein.

Authors: Chun Tang; Erin Loeliger; Paz Luncsford; Isaac Kinde; Dorothy Beckett; Michael F Summers
Journal: Proc Natl Acad Sci U S A Date: 2003-12-29 Impact factor: 11.205

3. Molecular dynamics analysis of HIV-1 matrix protein: clarifying differences between crystallographic and solution structures.

Authors: Hugo Verli; Alexandre Calazans; Rodrigo Brindeiro; Amilcar Tanuri; Jorge A Guimarães
Journal: J Mol Graph Model Date: 2006-09-26 Impact factor: 2.518

4. Characterization of an HIV-1 isolate displaying an apparent absence of virion-associated reverse transcriptase activity.

Authors: R W Buckheit; R Swanstrom
Journal: AIDS Res Hum Retroviruses Date: 1991-03 Impact factor: 2.205

5. O(NlogN) continuous electrostatics method for fast calculation of solvation energies of biomolecules.

Authors: P O Fedichev; E G Getmantsev; L I Menshikov
Journal: J Comput Chem Date: 2010-12-31 Impact factor: 3.376

6. Subgroup G HIV type 1 isolates from Nigeria.

Authors: A G Abimiku; T L Stern; A Zwandor; P D Markham; C Calef; S Kyari; W C Saxinger; R C Gallo; M Robert-Guroff; M S Reitz
Journal: AIDS Res Hum Retroviruses Date: 1994-11 Impact factor: 2.205

7. Development of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 and performance of an improved AMPLICOR HIV-1 MONITOR test with isolates of diverse subtypes.

Authors: N L Michael; S A Herman; S Kwok; K Dreyer; J Wang; C Christopherson; J P Spadoro; K K Young; V Polonis; F E McCutchan; J Carr; J R Mascola; L L Jagodzinski; M L Robb
Journal: J Clin Microbiol Date: 1999-08 Impact factor: 5.948

8. Performance of the Affymetrix GeneChip HIV PRT 440 platform for antiretroviral drug resistance genotyping of human immunodeficiency virus type 1 clades and viral isolates with length polymorphisms.

Authors: M Vahey; M E Nau; S Barrick; J D Cooley; R Sawyer; A A Sleeker; P Vickerman; S Bloor; B Larder; N L Michael; S A Wegner
Journal: J Clin Microbiol Date: 1999-08 Impact factor: 5.948

9. Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient gag membrane binding.

Authors: Vineela Chukkapalli; Ian B Hogue; Vitaly Boyko; Wei-Shau Hu; Akira Ono
Journal: J Virol Date: 2007-12-19 Impact factor: 5.103

10. Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.

Authors: C P Hill; D Worthylake; D P Bancroft; A M Christensen; W I Sundquist
Journal: Proc Natl Acad Sci U S A Date: 1996-04-02 Impact factor: 11.205

14 in total

1. Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.

Authors: Jimmy P Xu; Ashwanth C Francis; Megan E Meuser; Marie Mankowski; Roger G Ptak; Adel A Rashad; Gregory B Melikyan; Simon Cocklin
Journal: J Drug Des Res Date: 2018-08-13

2. Solution Conformation of Bovine Leukemia Virus Gag Suggests an Elongated Structure.

Authors: Dominic F Qualley; Sarah E Cooper; James L Ross; Erik D Olson; William A Cantara; Karin Musier-Forsyth
Journal: J Mol Biol Date: 2019-02-04 Impact factor: 5.469

3. Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement.

Authors: Marina Tuyishime; Matt Danish; Amy Princiotto; Marie K Mankowski; Rae Lawrence; Henry-Georges Lombart; Kirill Esikov; Joel Berniac; Kuang Liang; Jingjing Ji; Roger G Ptak; Navid Madani; Simon Cocklin
Journal: Bioorg Med Chem Lett Date: 2014-12-01 Impact factor: 2.823

Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.

1. Molecular modelling study of HIV p17gag (MA) protein shell utilising data from electron microscopy and X-ray crystallography.

2. Entropic switch regulates myristate exposure in the HIV-1 matrix protein.

3. Molecular dynamics analysis of HIV-1 matrix protein: clarifying differences between crystallographic and solution structures.

4. Characterization of an HIV-1 isolate displaying an apparent absence of virion-associated reverse transcriptase activity.

5. O(NlogN) continuous electrostatics method for fast calculation of solvation energies of biomolecules.

6. Subgroup G HIV type 1 isolates from Nigeria.

7. Development of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 and performance of an improved AMPLICOR HIV-1 MONITOR test with isolates of diverse subtypes.

8. Performance of the Affymetrix GeneChip HIV PRT 440 platform for antiretroviral drug resistance genotyping of human immunodeficiency virus type 1 clades and viral isolates with length polymorphisms.

9. Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient gag membrane binding.

10. Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.

1. Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.

2. Solution Conformation of Bovine Leukemia Virus Gag Suggests an Elongated Structure.

3. Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement.

Review 4. HIV-1 gag: an emerging target for antiretroviral therapy.

Review 5. Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses.

Review 6. HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors.

7. Structural and molecular determinants of HIV-1 Gag binding to the plasma membrane.

8. Functional conservation of HIV-1 Gag: implications for rational drug design.

9. Herb-target interaction network analysis helps to disclose molecular mechanism of traditional Chinese medicine.

10. Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication.