Literature DB >> 23303248

Femtomolar Zn(II) affinity of minimal zinc hook peptides--a promising small tag for protein engineering.

Tomasz Kochańczyk1, Piotr Jakimowicz, Artur Krężel.   

Abstract

The minimal zinc hook peptide of Rad50 and its alanine mutants form highly stable Zn(II) complexes. These peptides were successfully used as a small, efficient tag for reversible Zn(II)-mediated protein homodimerization. The high stability, its biological consequences and potential applications in protein engineering are discussed.

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Year:  2013        PMID： 23303248     DOI： 10.1039/c2cc38174e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Single Fluorescent Protein-Based Indicators for Zinc Ion (Zn(2+)).

Authors:  Zhijie Chen; Hui-Wang Ai
Journal:  Anal Chem       Date:  2016-08-29       Impact factor: 6.986

2.  Interdependence of the rad50 hook and globular domain functions.

Authors:  Marcel Hohl; Tomasz Kochańczyk; Cristina Tous; Andrés Aguilera; Artur Krężel; John H J Petrini
Journal:  Mol Cell       Date:  2015-01-15       Impact factor: 17.970

3.  Detection and Quantification of Tightly Bound Zn2+ in Blood Serum Using a Photocaged Chelator and a DNAzyme Fluorescent Sensor.

Authors:  Shige Xing; Yao Lin; Liangyuan Cai; Prem N Basa; Austin K Shigemoto; Chengbin Zheng; Feng Zhang; Shawn C Burdette; Yi Lu
Journal:  Anal Chem       Date:  2021-03-31       Impact factor: 8.008

4.  Metal-coupled folding as the driving force for the extreme stability of Rad50 zinc hook dimer assembly.

Authors:  Tomasz Kochańczyk; Michał Nowakowski; Dominika Wojewska; Anna Kocyła; Andrzej Ejchart; Wiktor Koźmiński; Artur Krężel
Journal:  Sci Rep       Date:  2016-11-03       Impact factor: 4.379

5.  Eukaryotic Rad50 functions as a rod-shaped dimer.

Authors:  Young Bong Park; Marcel Hohl; Michał Padjasek; Eunyoung Jeong; Kyeong Sik Jin; Artur Krężel; John H J Petrini; Yunje Cho
Journal:  Nat Struct Mol Biol       Date:  2017-01-30       Impact factor: 15.369

6.  Phytochelatins as a Dynamic System for Cd(II) Buffering from the Micro- to Femtomolar Range.

Authors:  Joanna Wątły; Marek Łuczkowski; Michał Padjasek; Artur Krężel
Journal:  Inorg Chem       Date:  2021-03-18       Impact factor: 5.165

7.  Relations between Structure and Zn(II) Binding Affinity Shed Light on the Mechanisms of Rad50 Hook Domain Functioning and Its Phosphorylation.

Authors:  Józef Ba Tran; Michał Padjasek; Artur Krężel
Journal:  Int J Mol Sci       Date:  2022-09-22       Impact factor: 6.208

8.  The biological inorganic chemistry of zinc ions.

Authors:  Artur Krężel; Wolfgang Maret
Journal:  Arch Biochem Biophys       Date:  2016-04-23       Impact factor: 4.013

Review 9.  Designing disorder: Tales of the unexpected tails.

Authors:  David P Minde; Els F Halff; Sander Tans
Journal:  Intrinsically Disord Proteins       Date:  2013-01-01
  9 in total

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