Literature DB >> 2329554

Nonpeptide angiotensin II receptor antagonists: N-[(benzyloxy)benzyl]imidazoles and related compounds as potent antihypertensives.

D J Carini1, J V Duncia, A L Johnson, A T Chiu, W A Price, P C Wong, P B Timmermans.   

Abstract

A series of compounds has been synthesized and demonstrated to be antagonists of the angiotensin II (AII) receptor. These compounds are structurally related to the N-(benzamidobenzyl)imidazoles and extend the scope of this new class of nonpeptide AII antagonists. It has been found that the amide linkage (X = NHCO) in the N-(benzamidobenzyl)imidazoles can be replaced successfully by a variety of groups (X = single bond, O, S, CO, OCH2, CH = CH, NHCONH); linkers of 0-1 atoms in length are most effective. When administered intravenously to awake renal hypertensive rats, these compounds are potent antihypertensives.

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Year:  1990        PMID： 2329554     DOI： 10.1021/jm00167a008

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  Structure-lipophilicity relationships of peptides and peptidomimetics.

Authors:  N El Tayar; H Karajiannis; H van de Waterbeemd
Journal:  Amino Acids       Date:  1995-06       Impact factor: 3.520

2.  A 3D QSAR CoMFA study of non-peptide angiotensin II receptor antagonists.

Authors:  L Belvisi; G Bravi; G Catalano; M Mabilia; A Salimbeni; C Scolastico
Journal:  J Comput Aided Mol Des       Date:  1996-12       Impact factor: 3.686

3.  Synthesis of imidazol-2-yl amino acids by using cells from alkane-oxidizing bacteria.

Authors:  Annett Mikolasch; Elke Hammer; Frieder Schauer
Journal:  Appl Environ Microbiol       Date:  2003-03       Impact factor: 4.792

4.  A 3D QSAR approach to the search for geometrical similarity in a series of nonpeptide angiotensin II receptor antagonists.

Authors:  L Belvisi; G Bravi; C Scolastico; A Vulpetti; A Salimbeni; R Todeschini
Journal:  J Comput Aided Mol Des       Date:  1994-04       Impact factor: 3.686

5.  Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype.

Authors:  L Criscione; M de Gasparo; P Bühlmayer; S Whitebread; H P Ramjoué; J Wood
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739
  5 in total

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