OBJECTIVE: To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital. SUBJECTS AND METHODS: The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil. RESULTS: We found that the T allele of the SNP rs7903146 of TCF7L2 was significantly associated with T2D risk (odds ratio of 3.92 for genotype TT in the recessive genetic model, p = 0.004 and 1.5 for T allele, p = 0.032). CONCLUSION: These results reinforce previous findings on the consistent association of this genetic factor and the risk of T2D in populations of diverse ethnic backgrounds.
OBJECTIVE: To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital. SUBJECTS AND METHODS: The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil. RESULTS: We found that the T allele of the SNP rs7903146 of TCF7L2 was significantly associated with T2D risk (odds ratio of 3.92 for genotype TT in the recessive genetic model, p = 0.004 and 1.5 for T allele, p = 0.032). CONCLUSION: These results reinforce previous findings on the consistent association of this genetic factor and the risk of T2D in populations of diverse ethnic backgrounds.
Authors: Małgorzata Wrzosek; Ada Sawicka; Michał Wrzosek; Paweł Piątkiewicz; Marek Tałałaj; Grażyna Nowicka Journal: Arch Med Sci Date: 2017-11-17 Impact factor: 3.318
Authors: Ali Mohammad Foroughmand; Sana Shafidelpour; Merhrnoosh Zakerkish; Mehdi Pourmehdi Borujeni Journal: Afr Health Sci Date: 2019-09 Impact factor: 0.927
Authors: Riobaldo Cintra; Filipe A Moura; Luiz S F Carvalho; Mauricio Daher; Simone N Santos; Ana P R Costa; Valeria N Figueiredo; Joalbo M Andrade; Francisco A R Neves; Jose C Quinaglia E Silva; Andrei C Sposito Journal: BBA Clin Date: 2016-04-02