OBJECTIVES: Many diffusion tensor imaging (DTI) studies have described the effects of hydrocephalus on periventricular white matter in patients with normal pressure hydrocephalus. However, little is known about hydrocephalus following stroke. We investigated the effect of hydrocephalus on periventricular white matter in patients with hydrocephalus after an intracerebral hemorrhage (ICH) using DTI. METHODS: Fourteen patients with ICH and hydrocephalus, and 17 age- and sex-matched normal control subjects were recruited. DTI parameters were estimated in six regions of interest (ROIs) in periventricular white matter: the anterior corona radiata, the posterior corona radiata, the genu of the corpus callosum, the splenium of corpus callosum, the anterior limb of the internal capsule, and the posterior limb of the internal capsule. RESULTS: Mean fractional anisotropy of the anterior corona radiata in patients was significantly higher than in controls (p < 0.05), but apparent diffusion coefficient (ADC) was not different in the two groups (p > 0.05). No significant differences between fractional anisotropies and ADCs were observed in the other five ROIs (p > 0.05). CONCLUSIONS: The anterior corona radiata was found to be more compressed by hydrocephalus than the other five regions of periventricular white matter examined in patients with hydrocephalus following ICH. It is believed that the results of the present study will be useful for the diagnosis and management of hydrocephalus following stroke.
OBJECTIVES: Many diffusion tensor imaging (DTI) studies have described the effects of hydrocephalus on periventricular white matter in patients with normal pressure hydrocephalus. However, little is known about hydrocephalus following stroke. We investigated the effect of hydrocephalus on periventricular white matter in patients with hydrocephalus after an intracerebral hemorrhage (ICH) using DTI. METHODS: Fourteen patients with ICH and hydrocephalus, and 17 age- and sex-matched normal control subjects were recruited. DTI parameters were estimated in six regions of interest (ROIs) in periventricular white matter: the anterior corona radiata, the posterior corona radiata, the genu of the corpus callosum, the splenium of corpus callosum, the anterior limb of the internal capsule, and the posterior limb of the internal capsule. RESULTS: Mean fractional anisotropy of the anterior corona radiata in patients was significantly higher than in controls (p < 0.05), but apparent diffusion coefficient (ADC) was not different in the two groups (p > 0.05). No significant differences between fractional anisotropies and ADCs were observed in the other five ROIs (p > 0.05). CONCLUSIONS: The anterior corona radiata was found to be more compressed by hydrocephalus than the other five regions of periventricular white matter examined in patients with hydrocephalus following ICH. It is believed that the results of the present study will be useful for the diagnosis and management of hydrocephalus following stroke.
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Authors: Francesco T Mangano; Charles B Stevenson; Usha Nagaraj; Adam Conley; Weihong Yuan Journal: Childs Nerv Syst Date: 2019-08-09 Impact factor: 1.475
Authors: Francesco T Mangano; Mekibib Altaye; Robert C McKinstry; Joshua S Shimony; Stephanie K Powell; Jannel M Phillips; Holly Barnard; David D Limbrick; Scott K Holland; Blaise V Jones; Jonathan Dodd; Sarah Simpson; Deanna Mercer; Akila Rajagopal; Sarah Bidwell; Weihong Yuan Journal: J Neurosurg Pediatr Date: 2016-05-20 Impact factor: 2.375
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Authors: Weihong Yuan; Scott K Holland; Joshua S Shimony; Mekibib Altaye; Francesco T Mangano; David D Limbrick; Blaise V Jones; Tiffany Nash; Akila Rajagopal; Sarah Simpson; Dustin Ragan; Robert C McKinstry Journal: Neuroimage Clin Date: 2015-04-29 Impact factor: 4.881
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Authors: Weihong Yuan; Artur Meller; Joshua S Shimony; Tiffany Nash; Blaise V Jones; Scott K Holland; Mekibib Altaye; Holly Barnard; Jannel Phillips; Stephanie Powell; Robert C McKinstry; David D Limbrick; Akila Rajagopal; Francesco T Mangano Journal: Neuroimage Clin Date: 2016-09-04 Impact factor: 4.881