Daniel Woo1, Andrew J Kruger2, Padmini Sekar2, Mary Haverbusch2, Jennifer Osborne2, Charles J Moomaw2, Sharyl Martini2, Shahla M Hosseini2, Simona Ferioli2, Bradford B Worrall2, Mitchell S V Elkind2, Gene Sung2, Michael L James2, Fernando D Testai2, Carl D Langefeld2, Joseph P Broderick2, Sebastian Koch2, Matthew L Flaherty2. 1. From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL. woodl@ucmail.uc.edu. 2. From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
Abstract
OBJECTIVE: We tested the hypothesis that intraventricular hemorrhage (IVH) is associated with incontinence and gait disturbance among survivors of intracerebral hemorrhage (ICH) at 3-month follow-ups. METHODS: The Genetic and Environmental Risk Factors for Hemorrhagic Stroke study was used as the discovery set. The Ethnic/Racial Variations of Intracerebral Hemorrhage study served as a replication set. Both studies performed prospective hot-pursuit recruitment of ICH cases with 3-month follow-up. Multivariable logistic regression analyses were computed to identify risk factors for incontinence and gait dysmobility at 3 months after ICH. RESULTS: The study population consisted of 307 ICH cases in the discovery set and 1,374 cases in the replication set. In the discovery set, we found that increasing IVH volume was associated with incontinence (odds ratio [OR] 1.50; 95% confidence interval [CI] 1.10-2.06) and dysmobility (OR 1.58; 95% CI 1.17-2.15) after controlling for ICH location, initial ICH volume, age, baseline modified Rankin Scale score, sex, and admission Glasgow Coma Scale score. In the replication set, increasing IVH volume was also associated with both incontinence (OR 1.42; 95% CI 1.27-1.60) and dysmobility (OR 1.40; 95% CI 1.24-1.57) after controlling for the same variables. CONCLUSION: ICH subjects with IVH extension are at an increased risk for developing incontinence and dysmobility after controlling for factors associated with severity and disability. This finding suggests a potential target to prevent or treat long-term disability after ICH with IVH.
OBJECTIVE: We tested the hypothesis that intraventricular hemorrhage (IVH) is associated with incontinence and gait disturbance among survivors of intracerebral hemorrhage (ICH) at 3-month follow-ups. METHODS: The Genetic and Environmental Risk Factors for Hemorrhagic Stroke study was used as the discovery set. The Ethnic/Racial Variations of Intracerebral Hemorrhage study served as a replication set. Both studies performed prospective hot-pursuit recruitment of ICH cases with 3-month follow-up. Multivariable logistic regression analyses were computed to identify risk factors for incontinence and gait dysmobility at 3 months after ICH. RESULTS: The study population consisted of 307 ICH cases in the discovery set and 1,374 cases in the replication set. In the discovery set, we found that increasing IVH volume was associated with incontinence (odds ratio [OR] 1.50; 95% confidence interval [CI] 1.10-2.06) and dysmobility (OR 1.58; 95% CI 1.17-2.15) after controlling for ICH location, initial ICH volume, age, baseline modified Rankin Scale score, sex, and admission Glasgow Coma Scale score. In the replication set, increasing IVH volume was also associated with both incontinence (OR 1.42; 95% CI 1.27-1.60) and dysmobility (OR 1.40; 95% CI 1.24-1.57) after controlling for the same variables. CONCLUSION:ICH subjects with IVH extension are at an increased risk for developing incontinence and dysmobility after controlling for factors associated with severity and disability. This finding suggests a potential target to prevent or treat long-term disability after ICH with IVH.
Authors: David W Newell; M Mohsin Shah; Robert Wilcox; Douglas R Hansmann; Erik Melnychuk; John Muschelli; Daniel F Hanley Journal: J Neurosurg Date: 2011-06-10 Impact factor: 5.115
Authors: Hen Hallevi; Nabeel S Dar; Andrew D Barreto; Miriam M Morales; Sheryl Martin-Schild; Anitha T Abraham; Kyle C Walker; Nicole R Gonzales; Kachikwu Illoh; James C Grotta; Sean I Savitz Journal: Crit Care Med Date: 2009-03 Impact factor: 7.598
Authors: Charlotte Jj van Asch; Merel Ja Luitse; Gabriël Je Rinkel; Ingeborg van der Tweel; Ale Algra; Catharina Jm Klijn Journal: Lancet Neurol Date: 2010-01-05 Impact factor: 44.182