AIM: To clarify the relationship of human rectal aberrant crypt foci and formation of colorectal polyp. METHODS: Eighty-nine subjects were recruited from the population of Japanese individuals who underwent polypectomy at Yokohama City University Hospital. All patients had baseline adenomas removed at year 0 colonoscopy. Aberrant crypt foci (ACF) were defined as lesions in which the crypts were more darkly stained with methylene blue than normal crypts and had larger diameters, often with oval or slit-like lumens and a thicker epithelial lining. RESULTS: A total of 366 ACFs were identified in 89 patients; all had baseline adenomas removed at the first examination (year 0) colonoscopy and returned for the second (year 1). ACF in the lower rectum were assessed at year 0 and study group were divided into two groups depend on ACF numbers, 0-3 or over 3. All participants were examined in the number and maximum size of adenoma. There was no statistical difference in number and maximum size of ACF at year 0, however, maximum size of adenoma was larger in over 3 group than 0-3 group at year 1. CONCLUSION: The number of ACF may be a predictive factor of relatively large adenoma incidence in the pilot phase study.
AIM: To clarify the relationship of human rectal aberrant crypt foci and formation of colorectal polyp. METHODS: Eighty-nine subjects were recruited from the population of Japanese individuals who underwent polypectomy at Yokohama City University Hospital. All patients had baseline adenomas removed at year 0 colonoscopy. Aberrant crypt foci (ACF) were defined as lesions in which the crypts were more darkly stained with methylene blue than normal crypts and had larger diameters, often with oval or slit-like lumens and a thicker epithelial lining. RESULTS: A total of 366 ACFs were identified in 89 patients; all had baseline adenomas removed at the first examination (year 0) colonoscopy and returned for the second (year 1). ACF in the lower rectum were assessed at year 0 and study group were divided into two groups depend on ACF numbers, 0-3 or over 3. All participants were examined in the number and maximum size of adenoma. There was no statistical difference in number and maximum size of ACF at year 0, however, maximum size of adenoma was larger in over 3 group than 0-3 group at year 1. CONCLUSION: The number of ACF may be a predictive factor of relatively large adenoma incidence in the pilot phase study.
Authors: David P Hurlstone; Mohammed Karajeh; David S Sanders; Sister K Drew; Simon S Cross Journal: Am J Gastroenterol Date: 2005-06 Impact factor: 10.864
Authors: Richard G Stevens; Helen Swede; Christopher D Heinen; Melissa Jablonski; Michael Grupka; Barry Ross; Melissa Parente; Jennifer S Tirnauer; Charles Giardina; Thiruchandurai V Rajan; Daniel W Rosenberg; Joel Levine Journal: Cancer Lett Date: 2006-09-06 Impact factor: 8.679
Authors: T Takayama; S Katsuki; Y Takahashi; M Ohi; S Nojiri; S Sakamaki; J Kato; K Kogawa; H Miyake; Y Niitsu Journal: N Engl J Med Date: 1998-10-29 Impact factor: 91.245
Authors: Robert E Schoen; Matthew Mutch; Christopher Rall; Sarah M Dry; David Seligson; Asad Umar; Paul Pinsky Journal: Gastrointest Endosc Date: 2008-02-21 Impact factor: 9.427
Authors: David A Drew; Allen Mo; James J Grady; Richard G Stevens; Joel B Levine; Bruce M Brenner; Joseph C Anderson; Faripour Forouhar; Michael J O'Brien; Thomas J Devers; Daniel W Rosenberg Journal: Mol Cancer Res Date: 2017-12-08 Impact factor: 5.852