BACKGROUND:Aberrant crypt foci (ACF) are the putative precursors to colorectal adenomas and may be useful as biomarkers. Knowledge of their natural history is essential to understanding their potential utility. OBJECTIVE: Our purpose was to examine ACF detection 1 year after initial observation. DESIGN: We conducted a multicenter study of ACF by using a standardized protocol. ACF in the rectum were assessed and subjects returned 1 year later to evaluate the natural history of the lesions. SETTING: Ancillary study to the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. RESULTS: Of 78 subjects enrolled, 64 (82%) returned for a repeat examination 1 year later. The mean age was 71 years, 70% were male, and 54% had a history of adenomatous polyps. At the initial examination, 66% of subjects had at least 1 ACF detected in the rectum, with a mean of 2.1 +/- 2.3 per person. One year later, 60% of these subjects had at least 1 of the original ACF reidentified, but only 43% of all ACF were reidentified. A total of 56% of subjects had new ACF identified. LIMITATIONS: These results are generated from the pilot phase. Improvements or change in technique over time could have influenced the results. CONCLUSIONS: A total of 60% of subjects who had ACF continued to have at least one ACF 1 year later, but less than half the specific ACF could be reidentified, and more than 50% of subjects had new ACF. These results imply a considerable dynamic to ACF detection over a 1-year period of observation.
RCT Entities:
BACKGROUND: Aberrant crypt foci (ACF) are the putative precursors to colorectal adenomas and may be useful as biomarkers. Knowledge of their natural history is essential to understanding their potential utility. OBJECTIVE: Our purpose was to examine ACF detection 1 year after initial observation. DESIGN: We conducted a multicenter study of ACF by using a standardized protocol. ACF in the rectum were assessed and subjects returned 1 year later to evaluate the natural history of the lesions. SETTING: Ancillary study to the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. RESULTS: Of 78 subjects enrolled, 64 (82%) returned for a repeat examination 1 year later. The mean age was 71 years, 70% were male, and 54% had a history of adenomatous polyps. At the initial examination, 66% of subjects had at least 1 ACF detected in the rectum, with a mean of 2.1 +/- 2.3 per person. One year later, 60% of these subjects had at least 1 of the original ACF reidentified, but only 43% of all ACF were reidentified. A total of 56% of subjects had new ACF identified. LIMITATIONS: These results are generated from the pilot phase. Improvements or change in technique over time could have influenced the results. CONCLUSIONS: A total of 60% of subjects who had ACF continued to have at least one ACF 1 year later, but less than half the specific ACF could be reidentified, and more than 50% of subjects had new ACF. These results imply a considerable dynamic to ACF detection over a 1-year period of observation.
Authors: Paul J Limburg; Michelle R Mahoney; Katie L Allen Ziegler; Stephen J Sontag; Robert E Schoen; Richard Benya; Michael J Lawson; David S Weinberg; Elena Stoffel; Michael Chiorean; Russell Heigh; Joel Levine; Gary Della'Zanna; Luz Rodriguez; Ellen Richmond; Christopher Gostout; Sumithra J Mandrekar; Thomas C Smyrk Journal: Cancer Prev Res (Phila) Date: 2011-01-05
Authors: Paul F Pinsky; James Fleshman; Matt Mutch; Christopher Rall; Aline Charabaty; David Seligson; Sarah Dry; Asad Umar; Robert E Schoen Journal: Cancer Prev Res (Phila) Date: 2010-06-22
Authors: Akshay K Gupta; Paul Pinsky; Christopher Rall; Matthew Mutch; Sarah Dry; David Seligson; Robert E Schoen Journal: Gastrointest Endosc Date: 2009-06-21 Impact factor: 9.427
Authors: Helen Swede; Thomas E Rohan; Herbert Yu; Joseph C Anderson; Richard G Stevens; Jane Brokaw; Joel Levine; Bruce M Brenner; Carl D Malchoff; Valerie B Duffy; Devon C Pleau; Daniel W Rosenberg Journal: Cancer Causes Control Date: 2008-12-09 Impact factor: 2.506