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Literature DB >> 23293063

Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability.

Ahmed A Eltoukhy¹, Delai Chen, Christopher A Alabi, Robert Langer, Daniel G Anderson.

Abstract

Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23293063 PMCID： PMC3824380 DOI： 10.1002/adma.201204346

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

19 in total

1. Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation.

Authors: Delai Chen; Kevin T Love; Yi Chen; Ahmed A Eltoukhy; Christian Kastrup; Gaurav Sahay; Alvin Jeon; Yizhou Dong; Kathryn A Whitehead; Daniel G Anderson
Journal: J Am Chem Soc Date: 2012-04-10 Impact factor: 15.419

2. Structural and functional consequences of poly(ethylene glycol) inclusion on DNA condensation for gene delivery.

Authors: Peter G Millili; Joshua A Selekman; Kory M Blocker; David A Johnson; Ulhas P Naik; Millicent O Sullivan
Journal: Microsc Res Tech Date: 2010-09 Impact factor: 2.769

3. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters).

Authors: Daniel G Anderson; Akin Akinc; Naushad Hossain; Robert Langer
Journal: Mol Ther Date: 2005-03 Impact factor: 11.454

Review 4. Nonviral gene delivery: principle, limitations, and recent progress.

Authors: Mohammed S Al-Dosari; Xiang Gao
Journal: AAPS J Date: 2009-10-16 Impact factor: 4.009

Review 5. Physical and chemical stability of drug nanoparticles.

Authors: Libo Wu; Jian Zhang; Wiwik Watanabe
Journal: Adv Drug Deliv Rev Date: 2011-02-21 Impact factor: 15.470

Review 6. Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives.

Authors: Michael Neu; Dagmar Fischer; Thomas Kissel
Journal: J Gene Med Date: 2005-08 Impact factor: 4.565

Review 7. Nanoparticle PEGylation for imaging and therapy.

Authors: Jesse V Jokerst; Tatsiana Lobovkina; Richard N Zare; Sanjiv S Gambhir
Journal: Nanomedicine (Lond) Date: 2011-06 Impact factor: 5.307

8. A polymer library approach to suicide gene therapy for cancer.

Authors: Daniel G Anderson; Weidan Peng; Akin Akinc; Naushad Hossain; Anat Kohn; Robert Padera; Robert Langer; Janet A Sawicki
Journal: Proc Natl Acad Sci U S A Date: 2004-11-01 Impact factor: 11.205

9. Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy.

Authors: Joel Sunshine; Jordan J Green; Kerry P Mahon; Fan Yang; Ahmed A Eltoukhy; David N Nguyen; Robert Langer; Daniel G Anderson
Journal: Adv Mater Date: 2009-08-15 Impact factor: 30.849

10. Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles.

Authors: Fan Yang; Seung-Woo Cho; Sun Mi Son; Said R Bogatyrev; Deepika Singh; Jordan J Green; Ying Mei; Sohyun Park; Suk Ho Bhang; Byung-Soo Kim; Robert Langer; Daniel G Anderson
Journal: Proc Natl Acad Sci U S A Date: 2009-10-05 Impact factor: 11.205

26 in total

1. Rationally Designed Polycationic Carriers for Potent Polymeric siRNA-Mediated Gene Silencing.

Authors: Connie Wu; Jiahe Li; Wade Wang; Paula T Hammond
Journal: ACS Nano Date: 2018-06-28 Impact factor: 15.881

2. Verteporfin-Loaded Poly(ethylene glycol)-Poly(beta-amino ester)-Poly(ethylene glycol) Triblock Micelles for Cancer Therapy.

Authors: Jayoung Kim; James G Shamul; Sagar R Shah; Alyssa Shin; Ben J Lee; Alfredo Quinones-Hinojosa; Jordan J Green
Journal: Biomacromolecules Date: 2018-07-23 Impact factor: 6.988

3. A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery.

Authors: David R Wilson; Denis Routkevitch; Yuan Rui; Arman Mosenia; Karl J Wahlin; Alfredo Quinones-Hinojosa; Donald J Zack; Jordan J Green
Journal: Mol Ther Date: 2017-05-04 Impact factor: 11.454

Review 4. Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities.

Authors: Johan Karlsson; Kelly R Rhodes; Jordan J Green; Stephany Y Tzeng
Journal: Expert Opin Drug Deliv Date: 2020-07-31 Impact factor: 6.648

5. The role of assembly parameters on polyplex poly(beta-amino ester) nanoparticle transfections.

Authors: David R Wilson; Mark P Suprenant; John H Michel; Ellen B Wang; Stephany Y Tzeng; Jordan J Green
Journal: Biotechnol Bioeng Date: 2019-01-29 Impact factor: 4.530

6. Differentially Branched Ester Amine Quadpolymers with Amphiphilic and pH-Sensitive Properties for Efficient Plasmid DNA Delivery.

Authors: David R Wilson; Yuan Rui; Kamran Siddiq; Denis Routkevitch; Jordan J Green
Journal: Mol Pharm Date: 2019-01-18 Impact factor: 4.939

7. Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing.

Authors: Yuan Rui; David R Wilson; Katie Sanders; Jordan J Green
Journal: ACS Appl Mater Interfaces Date: 2019-03-08 Impact factor: 9.229