OBJECTIVE: To identify predictors of poorer physical function in established psoriatic arthritis (PsA). METHODS: PsA patients with disease duration of ≥10 years were identified from the Bath longitudinal cohort. Physical function was assessed using the Stanford Health Assessment Questionnaire (HAQ). Sex, age at diagnosis, duration of symptoms prior to diagnosis, smoking, treatment and year of diagnosis were included in a multivariable regression analysis to identify associations with HAQ. RESULTS: 267 patients were identified for inclusion. The median age was 56 years (IQR 45-63), median disease duration was 13 years (IQR 10-18) and median HAQ score was 0.63 (IQR 0.13-1.25). The model predicted significant increases in HAQ related to smoking (0.23, 95% CI 0.04 to 0.42), age >50 years at diagnosis (0.27, 95% CI 0.03 to 0.51), symptom duration of ≥1 year before diagnosis (0.22, 95% CI 0.02 to 0.42), female sex (0.39, 95% CI 0.20 to 0.57) and history of treatment with an anti-TNF agent (0.63, 95% CI 0.32 to 0.93) at follow-up. CONCLUSIONS: Smoking, delay to diagnosis, older age at diagnosis, female sex and a history of anti-TNF treatment are associated with worse physical function in established PsA.
OBJECTIVE: To identify predictors of poorer physical function in established psoriatic arthritis (PsA). METHODS: PsA patients with disease duration of ≥10 years were identified from the Bath longitudinal cohort. Physical function was assessed using the Stanford Health Assessment Questionnaire (HAQ). Sex, age at diagnosis, duration of symptoms prior to diagnosis, smoking, treatment and year of diagnosis were included in a multivariable regression analysis to identify associations with HAQ. RESULTS: 267 patients were identified for inclusion. The median age was 56 years (IQR 45-63), median disease duration was 13 years (IQR 10-18) and median HAQ score was 0.63 (IQR 0.13-1.25). The model predicted significant increases in HAQ related to smoking (0.23, 95% CI 0.04 to 0.42), age >50 years at diagnosis (0.27, 95% CI 0.03 to 0.51), symptom duration of ≥1 year before diagnosis (0.22, 95% CI 0.02 to 0.42), female sex (0.39, 95% CI 0.20 to 0.57) and history of treatment with an anti-TNF agent (0.63, 95% CI 0.32 to 0.93) at follow-up. CONCLUSIONS: Smoking, delay to diagnosis, older age at diagnosis, female sex and a history of anti-TNF treatment are associated with worse physical function in established PsA.
Authors: Ann Bremander; Lennart T H Jacobsson; Stefan Bergman; Emma Haglund; Sofia Löfvendahl; Ingemar F Petersson Journal: Clin Rheumatol Date: 2014-07-15 Impact factor: 2.980
Authors: Alanna C Bridgman; Abrar A Qureshi; Tricia Li; Fred K Tabung; Eunyoung Cho; Aaron M Drucker Journal: J Am Acad Dermatol Date: 2019-02-21 Impact factor: 11.527
Authors: Ennio Lubrano; Andrea Delle Sedie; Marco Romanelli; Maria Sole Chimenti; Luca Bianchi; Stefano Piaserico; Catia De Felice; Dario Graceffa; Maria Ilenia De Andres; Salvatore Curatolo; Rosa Daniela Grembiale; Stefano Dastoli; Chiara Arcuri; Rosa Giuseppa Angileri; Francesca Prignano; Francesca Bandinelli; Elena Baldissera; Santo Raffaele Mercuri; Chiara Franchi; Matteo Longhi; Angela Patrì; Francesco Caso; Giuseppe Passiu; Maria Antonia Montesu; Simone Parisi; Elena Stroppiana; Genoveffa Scotto di Luzio; Giovanni Italiano; Sergio Di Nuzzo; Daniele Santilli; Laura Bigi; Federica Lumetti; Concetto Paolo Agnusdei; Maria Grazia Ferrucci; Giuliana Gualberti; Francesca Marando; Roberta Ramonda; Francesco Cusano Journal: Clin Rheumatol Date: 2020-11-06 Impact factor: 2.980