Alanna C Bridgman1, Abrar A Qureshi2, Tricia Li3, Fred K Tabung4, Eunyoung Cho5, Aaron M Drucker6. 1. School of Medicine, Queen's University, Kingston, Canada. 2. Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. 3. Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island. 4. Division of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. 5. Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. 6. Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada; Women's College Research Institute and Division of Dermatology, Department of Medicine, Women's College Hospital, Toronto, Canada. Electronic address: aaron.drucker@wchospital.ca.
Abstract
BACKGROUND: Diet is a modulator of inflammation that might impact inflammatory skin diseases. OBJECTIVE: To assess the relationship between pro-inflammatory dietary patterns and incident psoriasis, psoriatic arthritis (PsA), and atopic dermatitis (AD). METHODS: We conducted cohort studies among women in the Nurses' Health Study II. The Empirical Dietary Inflammatory Pattern (EDIP) score was calculated at baseline and every 4 years. Incident psoriasis, PsA, and AD were assessed by validated self-report. We used multivariable-adjusted Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between EDIP quintiles and risk for psoriasis, PsA, and AD. RESULTS: We had 85,185 participants in the psoriasis analysis and 63,443 in the AD analysis. There were 1432 cases of psoriasis, 262 cases of PsA, and 403 cases of AD. Pro-inflammatory dietary patterns were not associated with the risk for outcomes in multivariable models (all P values for trend >.05). HRs comparing the highest to the lowest EDIP quintile were 0.99 (95% CI 0.83-1.18) for psoriasis, 1.22 (95% CI 0.81-1.83) for PsA, and 0.96 (95% CI 0.69-1.34) for AD. LIMITATIONS: Recall and self-report. CONCLUSION: Our findings do not support dietary inflammatory potential as a risk factor for psoriasis, PsA, or AD.
BACKGROUND: Diet is a modulator of inflammation that might impact inflammatory skin diseases. OBJECTIVE: To assess the relationship between pro-inflammatory dietary patterns and incident psoriasis, psoriatic arthritis (PsA), and atopic dermatitis (AD). METHODS: We conducted cohort studies among women in the Nurses' Health Study II. The Empirical Dietary Inflammatory Pattern (EDIP) score was calculated at baseline and every 4 years. Incident psoriasis, PsA, and AD were assessed by validated self-report. We used multivariable-adjusted Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between EDIP quintiles and risk for psoriasis, PsA, and AD. RESULTS: We had 85,185 participants in the psoriasis analysis and 63,443 in the AD analysis. There were 1432 cases of psoriasis, 262 cases of PsA, and 403 cases of AD. Pro-inflammatory dietary patterns were not associated with the risk for outcomes in multivariable models (all P values for trend >.05). HRs comparing the highest to the lowest EDIP quintile were 0.99 (95% CI 0.83-1.18) for psoriasis, 1.22 (95% CI 0.81-1.83) for PsA, and 0.96 (95% CI 0.69-1.34) for AD. LIMITATIONS: Recall and self-report. CONCLUSION: Our findings do not support dietary inflammatory potential as a risk factor for psoriasis, PsA, or AD.
Authors: Fred K Tabung; Stephanie A Smith-Warner; Jorge E Chavarro; Teresa T Fung; Frank B Hu; Walter C Willett; Edward L Giovannucci Journal: J Nutr Date: 2017-06-28 Impact factor: 4.798
Authors: Anna Kablak-Ziembicka; Tadeusz Przewlocki; Andrzej Sokołowski; Wieslawa Tracz; Piotr Podolec Journal: Atherosclerosis Date: 2010-10-20 Impact factor: 5.162
Authors: M Elaine Husni; Kathryn H Meyer; Darel S Cohen; Elinor Mody; Abrar A Qureshi Journal: J Am Acad Dermatol Date: 2007-07-03 Impact factor: 11.527
Authors: Fred K Tabung; Li Liu; Weike Wang; Teresa T Fung; Kana Wu; Stephanie A Smith-Warner; Yin Cao; Frank B Hu; Shuji Ogino; Charles S Fuchs; Edward L Giovannucci Journal: JAMA Oncol Date: 2018-03-01 Impact factor: 31.777
Authors: Anne M Minihane; Sophie Vinoy; Wendy R Russell; Athanasia Baka; Helen M Roche; Kieran M Tuohy; Jessica L Teeling; Ellen E Blaak; Michael Fenech; David Vauzour; Harry J McArdle; Bas H A Kremer; Luc Sterkman; Katerina Vafeiadou; Massimo Massi Benedetti; Christine M Williams; Philip C Calder Journal: Br J Nutr Date: 2015-07-31 Impact factor: 3.718
Authors: Medha Barbhaiya; Sara Tedeschi; Jeffrey A Sparks; Cianna Leatherwood; Elizabeth W Karlson; Walter C Willett; Bing Lu; Karen H Costenbader Journal: Arthritis Care Res (Hoboken) Date: 2021-08-06 Impact factor: 5.178