Literature DB >> 23288574

The therapeutic effect of mitochondria-targeted antioxidant SkQ1 and Cistanche deserticola is associated with increased levels of tryptophan and kynurenine in the rat lens.

O A Snytnikova1, Yu P Tsentalovich, N A Stefanova, A Zh Fursova, R Kaptein, R Z Sagdeev, N G Kolosova.   

Abstract

Supplementation of senescence-accelerated OXYS rats with the mitochondria-targeted antioxidant SkQ1 and with the powder from Cistanche deserticola results in the deceleration of the cataract development and even in the improvement of lens transparency. The therapeutic effect of these preparations correlates with a significant elevation of tryptophan and kynurenine levels in the lens. This finding is attributed to a deceleration of the tryptophan and kynurenine oxidation due to antioxidant-assisted reduction of oxidative stress in the lens.

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Year:  2013        PMID： 23288574     DOI： 10.1134/S1607672912060087

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  11 in total

1.  Photochemistry of kynurenine, a tryptophan metabolite: properties of the triplet state.

Authors:  Yuri P Tsentalovich; Olga A Snytnikova; Peter S Sherin; Malcolm D E Forbes
Journal:  J Phys Chem A       Date:  2005-04-28       Impact factor: 2.781

2.  Novel protein modification by kynurenine in human lenses.

Authors:  Santiago Vazquez; J Andrew Aquilina; Joanne F Jamie; Margaret M Sheil; Roger J W Truscott
Journal:  J Biol Chem       Date:  2001-11-28       Impact factor: 5.157

3.  Major changes in human ocular UV protection with age.

Authors:  L M Bova; M H Sweeney; J F Jamie; R J Truscott
Journal:  Invest Ophthalmol Vis Sci       Date:  2001-01       Impact factor: 4.799

4.  Photochemical and thermal reactivity of kynurenine.

Authors:  Yuri P Tsentalovich; Olga A Snytnikova; Malcolm D E Forbes; Elena I Chernyak; Sergey V Morozov
Journal:  Exp Eye Res       Date:  2006-09-08       Impact factor: 3.467

5.  Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients.

Authors:  Isla M Streete; Joanne F Jamie; Roger J W Truscott
Journal:  Invest Ophthalmol Vis Sci       Date:  2004-11       Impact factor: 4.799

6.  Effects of Cistanche deserticola on behavior and signs of cataract and retinopathy in senescence-accelerated OXYS rats.

Authors:  Natalia A Stefanova; Anzhela Zh Fursova; Kanat N Sarsenbaev; Nataliya G Kolosova
Journal:  J Ethnopharmacol       Date:  2011-10-14       Impact factor: 4.360

7.  UV filter instability: consequences for the human lens.

Authors:  Lisa M Taylor; J Andrew Aquilina; Joanne F Jamie; Roger J W Truscott
Journal:  Exp Eye Res       Date:  2002-08       Impact factor: 3.467

8.  Kinetics and mechanism of thermal decomposition of kynurenines and biomolecular conjugates: ramifications for the modification of mammalian eye lens proteins.

Authors:  Lyudmila V Kopylova; Olga A Snytnikova; Elena I Chernyak; Sergey V Morozov; Malcolm D E Forbes; Yuri P Tsentalovich
Journal:  Org Biomol Chem       Date:  2009-06-01       Impact factor: 3.876

Review 9.  An attempt to prevent senescence: a mitochondrial approach.

Authors:  Vladimir P Skulachev; Vladimir N Anisimov; Yuri N Antonenko; Lora E Bakeeva; Boris V Chernyak; Valery P Erichev; Oleg F Filenko; Natalya I Kalinina; Valery I Kapelko; Natalya G Kolosova; Boris P Kopnin; Galina A Korshunova; Mikhail R Lichinitser; Lidia A Obukhova; Elena G Pasyukova; Oleg I Pisarenko; Vitaly A Roginsky; Enno K Ruuge; Ivan I Senin; Inna I Severina; Maxim V Skulachev; Irina M Spivak; Vadim N Tashlitsky; Vsevolod A Tkachuk; Mikhail Yu Vyssokikh; Lev S Yaguzhinsky; Dmitry B Zorov
Journal:  Biochim Biophys Acta       Date:  2008-12-29

10.  Tryptophan and kynurenine levels in lenses of Wistar and accelerated-senescence OXYS rats.

Authors:  Olga A Snytnikova; Lyudmila V Kopylova; Elena I Chernyak; Sergey V Morozov; Nataliya G Kolosova; Yuri P Tsentalovich
Journal:  Mol Vis       Date:  2009-12-16       Impact factor: 2.367
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  5 in total

1.  Ameliorative effects of SkQ1 eye drops on cataractogenesis in senescence-accelerated OXYS rats.

Authors:  Yuliya V Rumyantseva; Elena I Ryabchikova; Anjela Z Fursova; Nataliya G Kolosova
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2014-09-30       Impact factor: 3.117

2.  Effects of Phenylethanoid Glycosides Extracted from Herba Cistanches on the Learning and Memory of the APP/PSI Transgenic Mice with Alzheimer's Disease.

Authors:  Jianhua Yang; Bowei Ju; Junping Hu
Journal:  Biomed Res Int       Date:  2021-01-18       Impact factor: 3.411

Review 3.  Herba Cistanche (Rou Cong-Rong): One of the Best Pharmaceutical Gifts of Traditional Chinese Medicine.

Authors:  Zhiming Li; Huinuan Lin; Long Gu; Jingwen Gao; Chi-Meng Tzeng
Journal:  Front Pharmacol       Date:  2016-03-01       Impact factor: 5.810

4.  Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome.

Authors:  Vladimir V Brzheskiy; Elena L Efimova; Tatiana N Vorontsova; Vladimir N Alekseev; Olga G Gusarevich; Ksenia N Shaidurova; Alla A Ryabtseva; Olga M Andryukhina; Tatiana G Kamenskikh; Elena S Sumarokova; Eugeny S Miljudin; Eugeny A Egorov; Oleg I Lebedev; Alexander V Surov; Andrii R Korol; Illia O Nasinnyk; Pavel A Bezditko; Olena P Muzhychuk; Vladimir A Vygodin; Elena V Yani; Alla Y Savchenko; Elena M Karger; Oleg N Fedorkin; Alexander N Mironov; Victoria Ostapenko; Natalia A Popeko; Vladimir P Skulachev; Maxim V Skulachev
Journal:  Adv Ther       Date:  2015-12-11       Impact factor: 3.845

5.  SkQ1 Ophthalmic Solution for Dry Eye Treatment: Results of a Phase 2 Safety and Efficacy Clinical Study in the Environment and During Challenge in the Controlled Adverse Environment Model.

Authors:  Anton Petrov; Natalia Perekhvatova; Maxim Skulachev; Linda Stein; George Ousler
Journal:  Adv Ther       Date:  2016-01-05       Impact factor: 3.845
  5 in total

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