Literature DB >> 16839022

Photochemistry of kynurenine, a tryptophan metabolite: properties of the triplet state.

Yuri P Tsentalovich1, Olga A Snytnikova, Peter S Sherin, Malcolm D E Forbes.   

Abstract

Photolysis of aqueous kynurenine (KN) solutions results in the formation of triplet kynurenine TKN. In low pH solutions, triplet formation occurs with almost 100% efficiency, while in neutral solutions the triplet quantum yield is PhiT = 0.018 +/- 0.004. The dissociation constant of TKN, which is attributed to deprotonation of the anilino group, has a pKa value of 4.7. Similar triplet absorption spectra were obtained under direct and acetone-sensitized photolysis. The large difference in quantum yields as a function of pH is attributed to excited-state properties of the first excited singlet state of KN. The rate constant quenching for TKN by oxygen is kq = 2 x 10(9) M(-1) s(-1).

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Year:  2005        PMID： 16839022     DOI： 10.1021/jp045142k

Source DB:  PubMed          Journal:  J Phys Chem A        ISSN： 1089-5639            Impact factor:   2.781


  6 in total

1.  Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms.

Authors:  Vanessa M D'Costa; Tariq A Mukhtar; Tejal Patel; Kalinka Koteva; Nicholas Waglechner; Donald W Hughes; Gerard D Wright; Gianfranco De Pascale
Journal:  Antimicrob Agents Chemother       Date:  2011-11-14       Impact factor: 5.191

2.  Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract.

Authors:  Vadim V Yanshole; Lyudmila V Yanshole; Olga A Snytnikova; Yuri P Tsentalovich
Journal:  Metabolomics       Date:  2019-02-26       Impact factor: 4.290

3.  The therapeutic effect of mitochondria-targeted antioxidant SkQ1 and Cistanche deserticola is associated with increased levels of tryptophan and kynurenine in the rat lens.

Authors:  O A Snytnikova; Yu P Tsentalovich; N A Stefanova; A Zh Fursova; R Kaptein; R Z Sagdeev; N G Kolosova
Journal:  Dokl Biochem Biophys       Date:  2013-01-04       Impact factor: 0.788

4.  The effect of single and repeated UVB radiation on rabbit lens.

Authors:  Miroslav Fris; Jitka Cejková; Anna Midelfart
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2008-01-12       Impact factor: 3.117

5.  Nicotinamide adenine dinucleotide reduced (NADH) is a natural UV filter of certain bird lens.

Authors:  Nataliya A Osik; Ekaterina A Zelentsova; Kirill A Sharshov; Yuri P Tsentalovich
Journal:  Sci Rep       Date:  2022-10-07       Impact factor: 4.996

Review 6.  Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases.

Authors:  Jazmin Reyes Ocampo; Rafael Lugo Huitrón; Dinora González-Esquivel; Perla Ugalde-Muñiz; Anabel Jiménez-Anguiano; Benjamín Pineda; José Pedraza-Chaverri; Camilo Ríos; Verónica Pérez de la Cruz
Journal:  Oxid Med Cell Longev       Date:  2014-02-17       Impact factor: 6.543
  6 in total

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