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Literature DB >> 23287474

PI3K-Akt pathway regulates polycomb group protein and stem cell maintenance.

Yan Liu, Hao Yu, Stephen D Nimer.

Abstract

Entities: Chemical Disease Gene Species

Keywords: Akt; Bmi1; Ezh2; PI3K; polycomb group protein; stem cell

Mesh：

Substances：

Year: 2012 PMID： 23287474 PMCID： PMC3575444 DOI： 10.4161/cc.23379

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

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8 in total

1. Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.

Authors: Makiko Mochizuki-Kashio; Yuta Mishima; Satoru Miyagi; Masamitsu Negishi; Atsunori Saraya; Takaaki Konuma; Jun Shinga; Haruhiko Koseki; Atsushi Iwama
Journal: Blood Date: 2011-10-31 Impact factor: 22.113

Review 2. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation.

Authors: Keith W Orford; David T Scadden
Journal: Nat Rev Genet Date: 2008-02 Impact factor: 53.242

Review 3. Polycomb group proteins: navigators of lineage pathways led astray in cancer.

Authors: Adrian P Bracken; Kristian Helin
Journal: Nat Rev Cancer Date: 2009-11 Impact factor: 60.716

4. Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest.

Authors: Isabel Hidalgo; Antonio Herrera-Merchan; Jose Manuel Ligos; Laura Carramolino; Javier Nuñez; Fernando Martinez; Orlando Dominguez; Miguel Torres; Susana Gonzalez
Journal: Cell Stem Cell Date: 2012-11-02 Impact factor: 24.633

5. Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

Authors: Karim Nacerddine; Jean-Bernard Beaudry; Vasudeva Ginjala; Bart Westerman; Francesca Mattiroli; Ji-Ying Song; Henk van der Poel; Olga Balagué Ponz; Colin Pritchard; Paulien Cornelissen-Steijger; John Zevenhoven; Ellen Tanger; Titia K Sixma; Shridar Ganesan; Maarten van Lohuizen
Journal: J Clin Invest Date: 2012-04-16 Impact factor: 14.808

6. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells.

Authors: Omer H Yilmaz; Riccardo Valdez; Brian K Theisen; Wei Guo; David O Ferguson; Hong Wu; Sean J Morrison
Journal: Nature Date: 2006-04-05 Impact factor: 49.962

7. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

Authors: Tai-Lung Cha; Binhua P Zhou; Weiya Xia; Yadi Wu; Cheng-Chieh Yang; Chun-Te Chen; Bo Ping; Arie P Otte; Mien-Chie Hung
Journal: Science Date: 2005-10-14 Impact factor: 47.728

8. Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.

Authors: Yan Liu; Fan Liu; Hao Yu; Xinyang Zhao; Goro Sashida; Anthony Deblasio; Michael Harr; Qing-Bai She; Zhenbang Chen; Hui-Kuan Lin; Silvana Di Giandomenico; Shannon E Elf; Youyang Yang; Yasuhiko Miyata; Gang Huang; Silvia Menendez; Ingo K Mellinghoff; Neal Rosen; Pier Paolo Pandolfi; Cyrus V Hedvat; Stephen D Nimer
Journal: Sci Signal Date: 2012-10-23 Impact factor: 8.192