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Literature DB >> 19851313

Polycomb group proteins: navigators of lineage pathways led astray in cancer.

Abstract

The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.

Entities: Disease

Mesh：

Substances：

Year: 2009 PMID： 19851313 DOI： 10.1038/nrc2736

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

177 in total

1. The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.

Authors: Giuseppina Caretti; Monica Di Padova; Bruce Micales; Gary E Lyons; Vittorio Sartorelli
Journal: Genes Dev Date: 2004-11-01 Impact factor: 11.361

2. Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

Authors: Sophia W M Bruggeman; Merel E Valk-Lingbeek; Petra P M van der Stoop; Jacqueline J L Jacobs; Karin Kieboom; Ellen Tanger; Danielle Hulsman; Carly Leung; Yvan Arsenijevic; Silvia Marino; Maarten van Lohuizen
Journal: Genes Dev Date: 2005-06-15 Impact factor: 11.361

3. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

Authors: Nimet Maherali; Rupa Sridharan; Wei Xie; Jochen Utikal; Sarah Eminli; Katrin Arnold; Matthias Stadtfeld; Robin Yachechko; Jason Tchieu; Rudolf Jaenisch; Kathrin Plath; Konrad Hochedlinger
Journal: Cell Stem Cell Date: 2007-06-07 Impact factor: 24.633

4. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

Authors: Ye Zheng; Steven Z Josefowicz; Arnold Kas; Tin-Tin Chu; Marc A Gavin; Alexander Y Rudensky
Journal: Nature Date: 2007-01-21 Impact factor: 49.962

5. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.

Authors: G M Brodeur; R C Seeger; M Schwab; H E Varmus; J M Bishop
Journal: Science Date: 1984-06-08 Impact factor: 47.728

Review 6. The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control.

Authors: Claus Nerlov
Journal: Trends Cell Biol Date: 2007-07-19 Impact factor: 20.808

Review 7. RNA-Seq: a revolutionary tool for transcriptomics.

Authors: Zhong Wang; Mark Gerstein; Michael Snyder
Journal: Nat Rev Genet Date: 2009-01 Impact factor: 53.242

8. The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.

Authors: Rajani K Vangala; Marion S Heiss-Neumann; Janki S Rangatia; Sheo M Singh; Claudia Schoch; Daniel G Tenen; Wolfgang Hiddemann; Gerhard Behre
Journal: Blood Date: 2002-08-29 Impact factor: 22.113

9. Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia.

Authors: Su-Jiang Zhang; Li-Yuan Ma; Qiu-Hua Huang; Guo Li; Bai-Wei Gu; Xiao-Dong Gao; Jing-Yi Shi; Yue-Ying Wang; Li Gao; Xun Cai; Rui-Bao Ren; Jiang Zhu; Zhu Chen; Sai-Juan Chen
Journal: Proc Natl Acad Sci U S A Date: 2008-02-04 Impact factor: 11.205

10. Polycomb CBX7 has a unifying role in cellular lifespan.

Authors: Jesús Gil; David Bernard; Dolores Martínez; David Beach
Journal: Nat Cell Biol Date: 2003-11-30 Impact factor: 28.213

265 in total

Review 1. Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2.

Authors: Chiara Mozzetta; Julien Pontis; Slimane Ait-Si-Ali
Journal: Antioxid Redox Signal Date: 2014-12-19 Impact factor: 8.401

Review 2. Long non-coding RNAs and cancer: a new frontier of translational research?

Authors: R Spizzo; M I Almeida; A Colombatti; G A Calin
Journal: Oncogene Date: 2012-01-23 Impact factor: 9.867

Review 3. Targeting the epigenome with bioactive food components for cancer prevention.

Authors: Thomas Prates Ong; Fernando Salvador Moreno; Sharon Ann Ross
Journal: J Nutrigenet Nutrigenomics Date: 2012-02-22

Review 4. The dynamic interplay in chromatin remodeling factors polycomb and trithorax proteins in response to DNA damage.

Authors: Shuang Liu; Yongguang Tao; Xiang Chen; Ya Cao
Journal: Mol Biol Rep Date: 2011-12-28 Impact factor: 2.316

5. Quantitative assessment of chromatin immunoprecipitation grade antibodies directed against histone modifications reveals patterns of co-occurring marks on histone protein molecules.

Authors: Sally E Peach; Emily L Rudomin; Namrata D Udeshi; Steven A Carr; Jacob D Jaffe
Journal: Mol Cell Proteomics Date: 2012-03-21 Impact factor: 5.911