Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Hsp90@chromatin.nucleus: an emerging hub of a networker.

Literature DB >> 23286900

Hsp90@chromatin.nucleus: an emerging hub of a networker.

Abstract

The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in clinical trials as anticancer drugs. Recent studies have illuminated the unappreciated significance of this chaperone in chromatin transactions and this review focuses on its role in gene expression. By comparing the different mechanisms by which Hsp90 orchestrates transcriptional regulation, the review outlines the contributions of this function to the cellular and organismal phenotype. We chart exciting avenues for research to gain comprehensive insights in the chaperone's importance in cellular physiology, thereby presenting novel opportunities for therapeutic intervention.

Entities: Gene

Mesh：

Substances：

Year: 2013 PMID： 23286900 DOI： 10.1016/j.tcb.2012.11.007

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

Keyword Cloud
Cited

21 in total

Review 1. Protein quality control machinery in intracellular protozoan parasites: hopes and challenges for therapeutic targeting.

Authors: Mohammad Anas; Varsha Kumari; Niharika Gupta; Anuradha Dube; Niti Kumar
Journal: Cell Stress Chaperones Date: 2019-06-21 Impact factor: 3.667

Review 2. It's not magic - Hsp90 and its effects on genetic and epigenetic variation.

Authors: Rebecca A Zabinsky; Grace Alexandria Mason; Christine Queitsch; Daniel F Jarosz
Journal: Semin Cell Dev Biol Date: 2018-06-06 Impact factor: 7.727

Review 3. Mechanism of evolution by genetic assimilation : Equivalence and independence of genetic mutation and epigenetic modulation in phenotypic expression.

Authors: Ken Nishikawa; Akira R Kinjo
Journal: Biophys Rev Date: 2018-02-21

Review 4. Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.

Authors: Len Neckers; Brian Blagg; Timothy Haystead; Jane B Trepel; Luke Whitesell; Didier Picard
Journal: Cell Stress Chaperones Date: 2018-02-01 Impact factor: 3.667

5. Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler.

Authors: Frank J Echtenkamp; Zlata Gvozdenov; Nicholas L Adkins; Yang Zhang; Melinda Lynch-Day; Shinya Watanabe; Craig L Peterson; Brian C Freeman
Journal: Mol Cell Date: 2016-11-03 Impact factor: 17.970

6. Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription.

Authors: Lixia Liu; Yaotang Deng; Zhenming Zheng; Zihao Deng; Jinxin Zhang; Jieyou Li; Manfeng Liang; Xueqiong Zhou; Wenchong Tan; Hongjun Yang; Leonard M Neckers; Fei Zou; Xuemei Chen
Journal: Mol Cancer Ther Date: 2021-08-10 Impact factor: 6.009

Hsp90@chromatin.nucleus: an emerging hub of a networker.

Review 1. Protein quality control machinery in intracellular protozoan parasites: hopes and challenges for therapeutic targeting.

Review 2. It's not magic - Hsp90 and its effects on genetic and epigenetic variation.

Review 3. Mechanism of evolution by genetic assimilation : Equivalence and independence of genetic mutation and epigenetic modulation in phenotypic expression.

Review 4. Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.

5. Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler.

6. Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription.

7. Genome-Wide Analysis of Heat-Sensitive Alternative Splicing in Physcomitrella patens.

8. Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase.

9. Hsp90 Maintains Proteostasis of the Galactose Utilization Pathway To Prevent Cell Lethality.

Review 10. The Role of HSP90 in Preserving the Integrity of Genomes Against Transposons Is Evolutionarily Conserved.