| Literature DB >> 23284048 |
Norman Zielke1, Bruce A Edgar, Melvin L DePamphilis.
Abstract
Developmentally programmed polyploidy occurs by at least four different mechanisms, two of which (endoreduplication and endomitosis) involve switching from mitotic cell cycles to endocycles by the selective loss of mitotic cyclin-dependent kinase (CDK) activity and bypassing many of the processes of mitosis. Here we review the mechanisms of endoreplication, focusing on recent results from Drosophila and mice.Entities:
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Year: 2013 PMID: 23284048 PMCID: PMC3579398 DOI: 10.1101/cshperspect.a012948
Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN: 1943-0264 Impact factor: 10.005