AIM: To examine the relationship between angiogenesis and lymphangigenesis in recurrent pterygia. METHODS: Tissues from 34 excised recurrent pterygia (including 12 Grade 1, 10 Grade 2, and 12 Grade 3) were involved in the study and tissues from 7 nasal epibulbar conjunctivae segments were used as controls. Sections from each pterygium were immunostained with CD(31) and LYVE-1 monoclonal antibodies to evaluate lymphatic microvessel density (LMVD) and blood microvessel density (BMVD), and the relationship between LMVD and BMVD in the pterygium was examined. RESULTS: There was a large number of CD(31) ((+))LYVE-1((-)) blood vessels but only a few CD(31) ((+))LYVE-1((+)) lymphatic vessels in grades 1 and 2 pterygium. However, lymphatic vessels were dramatically increased in grade 3 pterygium. LMVD correlated closely with BMVD in all pterygia, including grades 1, 2 and 3 peterygium patients (all P values <0.01). Although both the density of blood and lymphatic vessels increased in recurrent pterygia, lymphatic vessels developed much faster than blood vessels, especially in grade 3 pterygia. CONCLUSION: There is a significant but not parallel relationship between angiogenesis and lymphangiogenesis in recurrent pterygium. The outgrowth of blood and lymphatic vessels provide evidence that immunological mechanism may play a role in the development and recurrence of pterygium.
AIM: To examine the relationship between angiogenesis and lymphangigenesis in recurrent pterygia. METHODS: Tissues from 34 excised recurrent pterygia (including 12 Grade 1, 10 Grade 2, and 12 Grade 3) were involved in the study and tissues from 7 nasal epibulbar conjunctivae segments were used as controls. Sections from each pterygium were immunostained with CD(31) and LYVE-1 monoclonal antibodies to evaluate lymphatic microvessel density (LMVD) and blood microvessel density (BMVD), and the relationship between LMVD and BMVD in the pterygium was examined. RESULTS: There was a large number of CD(31) ((+))LYVE-1((-)) blood vessels but only a few CD(31) ((+))LYVE-1((+)) lymphatic vessels in grades 1 and 2 pterygium. However, lymphatic vessels were dramatically increased in grade 3 pterygium. LMVD correlated closely with BMVD in all pterygia, including grades 1, 2 and 3 peterygium patients (all P values <0.01). Although both the density of blood and lymphatic vessels increased in recurrent pterygia, lymphatic vessels developed much faster than blood vessels, especially in grade 3 pterygia. CONCLUSION: There is a significant but not parallel relationship between angiogenesis and lymphangiogenesis in recurrent pterygium. The outgrowth of blood and lymphatic vessels provide evidence that immunological mechanism may play a role in the development and recurrence of pterygium.
Authors: Renhai Cao; Meit A Björndahl; Piotr Religa; Steve Clasper; Stina Garvin; Dagmar Galter; Björn Meister; Fumitaka Ikomi; Katerina Tritsaris; Steen Dissing; Toshio Ohhashi; David G Jackson; Yihai Cao Journal: Cancer Cell Date: 2004-10 Impact factor: 31.743
Authors: A N Witmer; B C van Blijswijk; J Dai; P Hofman; T A Partanen; G F Vrensen; R O Schlingemann Journal: J Pathol Date: 2001-11 Impact factor: 7.996
Authors: Molykutty John-Aryankalayil; Nicholas Dushku; Cynthia J Jaworski; Constance A Cox; Gregory Schultz; Janine A Smith; Keri E Ramsey; Dietrich A Stephan; Kenn A Freedman; Ted W Reid; Deborah A Carper Journal: Mol Vis Date: 2006-01-23 Impact factor: 2.367
Authors: Meit Björndahl; Renhai Cao; L Johan Nissen; Steve Clasper; Louise A Johnson; Yuan Xue; Zhongjun Zhou; David Jackson; Anker Jon Hansen; Yihai Cao Journal: Proc Natl Acad Sci U S A Date: 2005-10-17 Impact factor: 11.205