| Literature DB >> 15488757 |
Renhai Cao1, Meit A Björndahl, Piotr Religa, Steve Clasper, Stina Garvin, Dagmar Galter, Björn Meister, Fumitaka Ikomi, Katerina Tritsaris, Steen Dissing, Toshio Ohhashi, David G Jackson, Yihai Cao.
Abstract
Cancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several tumor-derived growth factors. Here we report that members of the PDGF family act as lymphangiogenic factors. In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB potently induced growth of lymphatic vessels. Expression of PDGF-BB in murine fibrosarcoma cells induced tumor lymphangiogenesis, leading to enhanced metastasis in lymph nodes. These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis.Entities:
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Year: 2004 PMID： 15488757 DOI： 10.1016/j.ccr.2004.08.034
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743