| Literature DB >> 23274997 |
Sung Jun Choi1, Joungmin Lee, Yu-Sin Jang, Jin Hwan Park, Sang Yup Lee, In Ho Kim.
Abstract
Clostridium acetobutylicum is an industrially important organism that produces acetone-butanol-ethanol (ABE). The main objective of this study was to characterize the effects of increased cell density on the production of ABE during the phase transition from acidogenesis to solventogenesis in C. acetobutylicum. The increased ABE productivity of C. acetobutylicum was obtained by increasing the cell density using a newly designed medium (designated C. a cetobutylicum medium 1; CAM1). The maximum OD(600) value of C. acetobutylicum ATCC 824 strain obtained with CAM1 was 19.7, which is 1.8 times higher than that obtained with clostridial growth medium (CGM). The overall ABE productivity obtained in the CAM1-fermetation of the ATCC 824 strain was 0.83 g/L/h, which is 1.5 times higher than that (0.55 g/L/h) obtained with CGM. However, the increased productivity obtained with CAM1 did not result in an increase in the final ABE titer, because phase transition occurred at a high titer of acids.Entities:
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Year: 2012 PMID： 23274997 DOI： 10.1007/s12275-012-2373-1
Source DB: PubMed Journal: J Microbiol ISSN： 1225-8873 Impact factor: 3.422