Literature DB >> 23274985

A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa.

Yu-Xiang Yang1, Zhen-Hua Xu, Yu-Qian Zhang, Jing Tian, Li-Xing Weng, Lian-Hui Wang.   

Abstract

Quorum sensing (QS) has been a novel target for the treatment of infectious diseases. Here structural analogs of Pseudomonas aeruginosa autoinducer N-acyl homoserine lactone (AHL) were investigated for QS inhibitor (QSI) activity and a novel QSI was discovered, N-decanoyl-L-homoserine benzyl ester (C2). Virulence assays showed that C2 down-regulated total protease and elastase activities, as well as the production of rhamnolipid, that are controlled by QS in P. aeruginosa wild-type strain PAO1 without affecting growth. C2 was also shown to inhibit swarming motility of PAO1. Using a microdilution checkerboard method, we identified synergistic interactions between C2 and several antibiotics, tobramycin, gentamycin, cefepime, and meropenem. Data from real-time RT-PCR suggested that C2 inhibited the expression of lasR (29.67%), lasI (21.57%), rhlR (28.20%), and rhlI (29.03%).

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Year:  2012        PMID： 23274985     DOI： 10.1007/s12275-012-2149-7

Source DB:  PubMed          Journal:  J Microbiol        ISSN： 1225-8873            Impact factor:   3.422


  41 in total

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2.  Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.

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Review 3.  The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa.

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Review 4.  Reversal of resistance in microorganisms by help of non-antibiotics.

Authors:  Jette E Kristiansen; Oliver Hendricks; Thomas Delvin; Trine S Butterworth; Lone Aagaard; Jørn B Christensen; Vivian C Flores; Hendrik Keyzer
Journal:  J Antimicrob Chemother       Date:  2007-04-02       Impact factor: 5.790

5.  Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer.

Authors:  Kristina M Smith; Yigong Bu; Hiroaki Suga
Journal:  Chem Biol       Date:  2003-06

6.  Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication.

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7.  Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs.

Authors:  Kristina M Smith; Yigong Bu; Hiroaki Suga
Journal:  Chem Biol       Date:  2003-01

8.  Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.

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9.  Functional analysis of the Pseudomonas aeruginosa autoinducer PAI.

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  25 in total

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Review 2.  Protective role of gut commensal microbes against intestinal infections.

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Review 3.  Biofilm formation and inhibition mediated by bacterial quorum sensing.

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4.  The gut microbiome: a new frontier for alcohol investigation.

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5.  Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR Pseudomonas aeruginosa Strains.

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Review 6.  Foodborne ESKAPE Biofilms and Antimicrobial Resistance: lessons Learned from Clinical Isolates.

Authors:  Amrita Patil; Rajashri Banerji; Poonam Kanojiya; Sunil D Saroj
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7.  Autoinducer-2 regulates Pseudomonas aeruginosa PAO1 biofilm formation and virulence production in a dose-dependent manner.

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Journal:  BMC Microbiol       Date:  2015-09-29       Impact factor: 3.605

8.  Effect of Titanium Dioxide Nanoparticles on the Expression of Efflux Pump and Quorum-Sensing Genes in MDR Pseudomonas aeruginosa Isolates.

Authors:  Fatma Y Ahmed; Usama Farghaly Aly; Rehab Mahmoud Abd El-Baky; Nancy G F M Waly
Journal:  Antibiotics (Basel)       Date:  2021-05-24

9.  2-Heptylcyclopropane-1-Carboxylic Acid Disperses and Inhibits Bacterial Biofilms.

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Review 10.  Development of quorum-based anti-virulence therapeutics targeting Gram-negative bacterial pathogens.

Authors:  Song Buck Tay; Wen Shan Yew
Journal:  Int J Mol Sci       Date:  2013-08-09       Impact factor: 5.923
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