BACKGROUND: Acoustic radiation force impulse (ARFI) imaging) is correlated with histopathological findings using METAVIR and semiquantitative scoring system (SSS) criteria for liver fibrosis. OBJECTIVE: To compare acoustic radiation force impulse imaging with biopsy results in the evaluation of liver fibrosis in children. MATERIALS AND METHODS: Children with chronic liver disease and healthy children underwent acoustic radiation force impulse imaging liver measurements. ARFI gives a shear-wave velocity corresponding to tissue elasticity. In 39 children with liver disease, the values obtained were correlated with biopsy results. Receiver-operating characteristic (ROC) curves were used to determine the reliability of ARFI in estimating liver fibrosis in children. RESULTS: ARFI mean value was 1.12 in the healthy group and 1.99 in children with chronic liver disease. ROC curves show that an ARFI cutoff of 1.34 m/s is predictive of both METAVIR and SSS scores with a sensitivity of SSS > 2:0.85; METAVIR > F0:0.82. A cutoff of 2 m/s yielded a sensitivity of 100% to detect SSS > 4 or METAVIR > F2. CONCLUSION: Acoustic radiation force impulse imaging is a reliable, noninvasive and rapid method to estimate moderate to severe liver fibrosis in children. It might prove useful to clinicians for fibrosis monitoring in children with liver disease and postpone the time of liver biopsy.
BACKGROUND: Acoustic radiation force impulse (ARFI) imaging) is correlated with histopathological findings using METAVIR and semiquantitative scoring system (SSS) criteria for liver fibrosis. OBJECTIVE: To compare acoustic radiation force impulse imaging with biopsy results in the evaluation of liver fibrosis in children. MATERIALS AND METHODS:Children with chronic liver disease and healthy children underwent acoustic radiation force impulse imaging liver measurements. ARFI gives a shear-wave velocity corresponding to tissue elasticity. In 39 children with liver disease, the values obtained were correlated with biopsy results. Receiver-operating characteristic (ROC) curves were used to determine the reliability of ARFI in estimating liver fibrosis in children. RESULTS: ARFI mean value was 1.12 in the healthy group and 1.99 in children with chronic liver disease. ROC curves show that an ARFI cutoff of 1.34 m/s is predictive of both METAVIR and SSS scores with a sensitivity of SSS > 2:0.85; METAVIR > F0:0.82. A cutoff of 2 m/s yielded a sensitivity of 100% to detect SSS > 4 or METAVIR > F2. CONCLUSION: Acoustic radiation force impulse imaging is a reliable, noninvasive and rapid method to estimate moderate to severe liver fibrosis in children. It might prove useful to clinicians for fibrosis monitoring in children with liver disease and postpone the time of liver biopsy.
Authors: Mireen Friedrich-Rust; Katrin Wunder; Susanne Kriener; Fariba Sotoudeh; Swantje Richter; Joerg Bojunga; Eva Herrmann; Thierry Poynard; Christoph F Dietrich; Johannes Vermehren; Stefan Zeuzem; Christoph Sarrazin Journal: Radiology Date: 2009-08 Impact factor: 11.105
Authors: Jonathan R Dillman; Amer Heider; Jacob L Bilhartz; Ethan A Smith; Nahid Keshavarzi; Jonathan M Rubin; M James Lopez Journal: Pediatr Radiol Date: 2015-04-08
Authors: Sylviane Hanquinet; Delphine S Courvoisier; Anne-Laure Rougemont; Amira Dhouib; Laura Rubbia-Brandt; Barbara E Wildhaber; Laura Merlini; Valerie A McLin; Mehrak Anooshiravani Journal: Pediatr Radiol Date: 2015-05-06
Authors: Sylviane Hanquinet; Delphine S Courvoisier; Anne-Laure Rougemont; Barbara E Wildhaber; Laura Merlini; Valérie A McLin; Mehrak Anooshiravani Journal: Pediatr Radiol Date: 2016-03-03
Authors: Jonathan R Dillman; Shigao Chen; Matthew S Davenport; Heng Zhao; Matthew W Urban; Pengfei Song; Kuanwong Watcharotone; Paul L Carson Journal: Pediatr Radiol Date: 2014-09-24