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Literature DB >> 23269844

Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations.

Natalia L Komarova¹, Daniela Anghelina, Igor Voznesensky, Benjamin Trinité, David N Levy, Dominik Wodarz.

Abstract

Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.

Entities: Species

Mesh：

Year: 2012 PMID： 23269844 PMCID： PMC3565528 DOI： 10.1098/rsbl.2012.1049

Source DB: PubMed Journal: Biol Lett ISSN： 1744-9561 Impact factor: 3.703

16 in total

Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations.

1. Population doubling time, phosphatase activity, and hydrogen peroxide generation in Jurkat cells.

2. Dynamics of HIV-1 recombination in its natural target cells.

3. Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy.

4. Multiploid inheritance of HIV-1 during cell-to-cell infection.

5. Antiretroviral agents effectively block HIV replication after cell-to-cell transfer.

6. Inefficient human immunodeficiency virus replication in mobile lymphocytes.

7. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses.

8. Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies.

9. HIV-1 Virological Synapse: Live Imaging of Transmission.

Review 10. Avoiding the void: cell-to-cell spread of human viruses.

1. Effect of synaptic cell-to-cell transmission and recombination on the evolution of double mutants in HIV.

2. A reaction-diffusion within-host HIV model with cell-to-cell transmission.

3. On the laws of virus spread through cell populations.

4. Contribution of HIV-1 genomes that do not integrate to the basic reproductive ratio of the virus.

5. Understanding Willingness to Participate in HIV Biomedical Research: A Mixed Methods Investigation.

6. Synaptic transmission may provide an evolutionary benefit to HIV through modulation of latency.

7. Dynamics of HIV infection in lymphoid tissue network.

Review 8. Modeling the within-host dynamics of HIV infection.

9. Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection.

10. Cell-to-cell infection by HIV contributes over half of virus infection.