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Literature DB >> 23269809

Unraveling of a neutralization mechanism by two human antibodies against conserved epitopes in the globular head of H5 hemagglutinin.

Mengran Qian¹, Hongxing Hu, Teng Zuo, Guiqin Wang, Linqi Zhang, Paul Zhou.

Abstract

The rapid spread of highly pathogenic avian influenza (HPAI) H5N1 virus underscores the importance of effective antiviral treatment. Previously, we developed human monoclonal antibodies 65C6 and 100F4 that neutralize almost all (sub)clades of HPAI H5N1. The conserved 65C6 epitope was mapped to the globular head of HA. However, neither the 100F4 epitope nor the neutralization mechanism by these antibodies was known. In this study, we determined the 100F4 epitope and unraveled a neutralization mechanism by antibodies 65C6 and 100F4.

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Year: 2012 PMID： 23269809 PMCID： PMC3592130 DOI： 10.1128/JVI.01292-12

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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