Literature DB >> 23269805

Amino acid 316 of hemagglutinin and the neuraminidase stalk length influence virulence of H9N2 influenza virus in chickens and mice.

Yipeng Sun1, Yuanyuan Tan, Kai Wei, Honglei Sun, Yi Shi, Juan Pu, Hanchun Yang, George F Gao, Yanbo Yin, Wenhai Feng, Daniel R Perez, Jinhua Liu.   

Abstract

H9N2 influenza viruses with an A316S substitution in hemagglutinin (HA) and a shorter neuraminidase (NA) stalk have become predominant in China. The A316S was shown to increase HA cleavage efficiency when combined with short stalk NA, and the short stalk NA improved NA enzyme activity and release of virus from erythrocytes. Single mutations or combinations of these mutations strengthened the virulence of H9N2 virus in chickens and mice.

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Year:  2012        PMID： 23269805      PMCID： PMC3571412          DOI： 10.1128/JVI.02688-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  28 in total

1.  Biologic effects of introducing additional basic amino acid residues into the hemagglutinin cleavage site of a virulent avian influenza virus.

Authors:  T Horimoto; Y Kawaoka
Journal:  Virus Res       Date:  1997-07       Impact factor: 3.303

2.  Phylogenetic analysis of influenza A viruses (H6N8, H1N8, H4N2, H9N2, H10N7) isolated from wild birds, ducks, and ostriches in South Africa from 2007 to 2009.

Authors:  Celia Abolnik; Gertruida H Gerdes; Marna Sinclair; Boto W Ganzevoort; James P Kitching; Christina E Burger; Marco Romito; Magdeline Dreyer; Stefan Swanepoel; Graeme S Cumming; Adriaan J Olivier
Journal:  Avian Dis       Date:  2010-03       Impact factor: 1.577

3.  Improvement of influenza A/Fujian/411/02 (H3N2) virus growth in embryonated chicken eggs by balancing the hemagglutinin and neuraminidase activities, using reverse genetics.

Authors:  Bin Lu; Helen Zhou; Dan Ye; George Kemble; Hong Jin
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

4.  Insertion of a multibasic cleavage motif into the hemagglutinin of a low-pathogenic avian influenza H6N1 virus induces a highly pathogenic phenotype.

Authors:  Vincent J Munster; Eefje J A Schrauwen; Emmie de Wit; Judith M A van den Brand; Theo M Bestebroer; Sander Herfst; Guus F Rimmelzwaan; Albert D M E Osterhaus; Ron A M Fouchier
Journal:  J Virol       Date:  2010-06-02       Impact factor: 5.103

5.  Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice.

Authors:  Yumiko Matsuoka; David E Swayne; Colleen Thomas; Marie-Anne Rameix-Welti; Nadia Naffakh; Christine Warnes; Melanie Altholtz; Ruben Donis; Kanta Subbarao
Journal:  J Virol       Date:  2009-02-18       Impact factor: 5.103

6.  The genesis and evolution of H9N2 influenza viruses in poultry from southern China, 2000 to 2005.

Authors:  K M Xu; G J D Smith; J Bahl; L Duan; H Tai; D Vijaykrishna; J Wang; J X Zhang; K S Li; X H Fan; R G Webster; H Chen; J S M Peiris; Y Guan
Journal:  J Virol       Date:  2007-07-25       Impact factor: 5.103

7.  Antigenic and genetic characterization of H9N2 swine influenza viruses in China.

Authors:  Yan L Cong; Juan Pu; Qin F Liu; Shuai Wang; Guo Z Zhang; Xing L Zhang; Wei X Fan; Earl G Brown; Jin H Liu
Journal:  J Gen Virol       Date:  2007-07       Impact factor: 3.891

8.  The special neuraminidase stalk-motif responsible for increased virulence and pathogenesis of H5N1 influenza A virus.

Authors:  Hongbo Zhou; Zhengjun Yu; Yong Hu; Jiagang Tu; Wei Zou; Yaping Peng; Jiping Zhu; Yongtao Li; Anding Zhang; Ziniu Yu; Zhiping Ye; Huanchun Chen; Meilin Jin
Journal:  PLoS One       Date:  2009-07-17       Impact factor: 3.240

9.  The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties.

Authors:  M Matrosovich; N Zhou; Y Kawaoka; R Webster
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

10.  Evidence of expanded host range and mammalian-associated genetic changes in a duck H9N2 influenza virus following adaptation in quail and chickens.

Authors:  Md Jaber Hossain; Danielle Hickman; Daniel R Perez
Journal:  PLoS One       Date:  2008-09-09       Impact factor: 3.240
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  40 in total

1.  Sequence and phylogenetic analysis of surface protein genes of emerging H9N2 influenza viruses isolated from poultry in two geographical regions of China.

Authors:  Yu Xue; Jing-Lan Wang; Zhuan-Qiang Yan; Guang-Wei Li; Shun-Yan Chen; Xiang-Bin Zhang; Jian-Ping Qin; Hai-Yan Li; Shuang Chang; Feng Chen; Ying-Zuo Bee; Qing-Mei Xie
Journal:  Virus Genes       Date:  2014-03-30       Impact factor: 2.332

2.  Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice.

Authors:  Yuhai Bi; Haixia Xiao; Quanjiao Chen; Yan Wu; Lifeng Fu; Chuansong Quan; Gary Wong; Jun Liu; Joel Haywood; Yingxia Liu; Boping Zhou; Jinghua Yan; Wenjun Liu; George F Gao
Journal:  J Virol       Date:  2015-12-09       Impact factor: 5.103

3.  Influenza H7N9 and H9N2 viruses: coexistence in poultry linked to human H7N9 infection and genome characteristics.

Authors:  Xinfen Yu; Tao Jin; Yujun Cui; Xiaoying Pu; Jun Li; Jin Xu; Guang Liu; Huijue Jia; Dan Liu; Shili Song; Yang Yu; Li Xie; Renjie Huang; Hua Ding; Yu Kou; Yinyan Zhou; Yayu Wang; Xun Xu; Ye Yin; Jian Wang; Chenyi Guo; Xianwei Yang; Liangping Hu; Xiaopeng Wu; Hailong Wang; Jun Liu; Guoqiu Zhao; Jiyong Zhou; Jingcao Pan; George F Gao; Ruifu Yang; Jun Wang
Journal:  J Virol       Date:  2014-01-08       Impact factor: 5.103

4.  Detection of neuraminidase stalk motifs associated with enhanced N1 subtype influenza A virulence via Raman spectroscopy.

Authors:  JooYoung Choi; Sharon J H Martin; Ralph A Tripp; S Mark Tompkins; Richard A Dluhy
Journal:  Analyst       Date:  2015-11-21       Impact factor: 4.616

5.  Reassortment with dominant chicken H9N2 influenza virus contributed to the fifth H7N9 virus human epidemic.

Authors:  Juan Pu; Yanbo Yin; Jiyu Liu; Xinyu Wang; Yong Zhou; Zejiang Wang; Yipeng Sun; Honglei Sun; Fangtao Li; Jingwei Song; Runkang Qu; Weihua Gao; Dongdong Wang; Zhen Wang; Shijie Yan; Mingyue Chen; Jinfeng Zeng; Zhimin Jiang; Haoran Sun; Yanan Zong; Chenxi Wang; Qi Tong; Yuhai Bi; Yinhua Huang; Xiangjun Du; Kin-Chow Chang; Jinhua Liu
Journal:  J Virol       Date:  2021-03-17       Impact factor: 5.103

6.  A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice.

Authors:  Qiaoyang Teng; Dawei Xu; Weixia Shen; Qinfang Liu; Guangyu Rong; Xuesong Li; Liping Yan; Jianmei Yang; Hongjun Chen; Hai Yu; Wenjun Ma; Zejun Li
Journal:  J Virol       Date:  2016-10-14       Impact factor: 5.103

7.  Replication and transmission of mammalian-adapted H9 subtype influenza virus in pigs and quail.

Authors:  Adebimpe O Obadan; Brian J Kimble; Daniela Rajao; Kelly Lager; Jefferson J S Santos; Amy Vincent; Daniel R Perez
Journal:  J Gen Virol       Date:  2015-05-18       Impact factor: 3.891

Review 8.  Molecular determinants of influenza virus pathogenesis in mice.

Authors:  Ram P Kamal; Jaqueline M Katz; Ian A York
Journal:  Curr Top Microbiol Immunol       Date:  2014       Impact factor: 4.291

9.  Molecular characterization and phylogenetic analysis of H3 subtype avian influenza viruses isolated from domestic ducks in Zhejiang Province in China.

Authors:  Haibo Wu; Nanping Wu; Xiaorong Peng; Changzhong Jin; Xiangyun Lu; Linfang Cheng; Hangping Yao; Lanjuan Li
Journal:  Virus Genes       Date:  2014-04-20       Impact factor: 2.332

10.  Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity.

Authors:  Guanlong Xu; Xuxiao Zhang; Weihua Gao; Chenxi Wang; Jinliang Wang; Honglei Sun; Yipeng Sun; Lu Guo; Rui Zhang; Kin-Chow Chang; Jinhua Liu; Juan Pu
Journal:  J Virol       Date:  2016-08-26       Impact factor: 5.103
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