Literature DB >> 26656694

Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice.

Yuhai Bi1, Haixia Xiao2, Quanjiao Chen3, Yan Wu4, Lifeng Fu4, Chuansong Quan5, Gary Wong4, Jun Liu6, Joel Haywood4, Yingxia Liu7, Boping Zhou7, Jinghua Yan4, Wenjun Liu8, George F Gao9.   

Abstract

The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19- to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26656694      PMCID： PMC4734013          DOI： 10.1128/JVI.02553-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Changes in the haemagglutinin and the neuraminidase genes prior to the emergence of highly pathogenic H7N1 avian influenza viruses in Italy.

Authors:  J Banks; E S Speidel; E Moore; L Plowright; A Piccirillo; I Capua; P Cordioli; A Fioretti; D J Alexander
Journal:  Arch Virol       Date:  2001       Impact factor: 2.574

2.  Increase in viral yield in eggs and MDCK cells of reassortant H5N1 vaccine candidate viruses caused by insertion of 38 amino acids into the NA stalk.

Authors:  Wenjun Zhang; Tao Xue; Xiaowei Wu; Pinghu Zhang; Guo Zhao; Daxing Peng; Shunlin Hu; Xiaoquan Wang; Xiaowen Liu; Wenbo Liu; Xiufan Liu
Journal:  Vaccine       Date:  2011-08-22       Impact factor: 3.641

3.  Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets.

Authors:  Hui-Ling Yen; Chi-Hui Liang; Chung-Yi Wu; Heather L Forrest; Angela Ferguson; Ka-Tim Choy; Jeremy Jones; Diana Dik-Yan Wong; Peter Pak-Hang Cheung; Che-Hsiung Hsu; Olive T Li; Kit M Yuen; Renee W Y Chan; Leo L M Poon; Michael C W Chan; John M Nicholls; Scott Krauss; Chi-Huey Wong; Yi Guan; Robert G Webster; Richard J Webby; Malik Peiris
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-08       Impact factor: 11.205

4.  Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 H1N1 influenza pandemic.

Authors:  Rui Xu; Xueyong Zhu; Ryan McBride; Corwin M Nycholat; Wenli Yu; James C Paulson; Ian A Wilson
Journal:  J Virol       Date:  2012-06-20       Impact factor: 5.103

5.  Balanced hemagglutinin and neuraminidase activities are critical for efficient replication of influenza A virus.

Authors:  L J Mitnaul; M N Matrosovich; M R Castrucci; A B Tuzikov; N V Bovin; D Kobasa; Y Kawaoka
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

6.  A 27-amino-acid deletion in the neuraminidase stalk supports replication of an avian H2N2 influenza A virus in the respiratory tract of chickens.

Authors:  Erin M Sorrell; Haichen Song; Lindomar Pena; Daniel R Perez
Journal:  J Virol       Date:  2010-09-08       Impact factor: 5.103

7.  A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity and neurovirulence of H5N1 influenza virus in mice.

Authors:  Yi Zhang; Yipeng Sun; Honglei Sun; Juan Pu; Yuhai Bi; Yi Shi; Xishan Lu; Jing Li; Qingyu Zhu; George F Gao; Hanchun Yang; Jinhua Liu
Journal:  J Virol       Date:  2012-04-11       Impact factor: 5.103

8.  Assessment of the internal genes of influenza A (H7N9) virus contributing to high pathogenicity in mice.

Authors:  Yuhai Bi; Qing Xie; Shuang Zhang; Yun Li; Haixia Xiao; Tao Jin; Weinan Zheng; Jing Li; Xiaojuan Jia; Lei Sun; Jinhua Liu; Chuan Qin; George F Gao; Wenjun Liu
Journal:  J Virol       Date:  2014-10-15       Impact factor: 5.103

9.  A genetically engineered waterfowl influenza virus with a deletion in the stalk of the neuraminidase has increased virulence for chickens.

Authors:  S Munier; T Larcher; F Cormier-Aline; D Soubieux; B Su; L Guigand; B Labrosse; Y Cherel; P Quéré; D Marc; N Naffakh
Journal:  J Virol       Date:  2009-11-04       Impact factor: 5.103

10.  Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice.

Authors:  Yumiko Matsuoka; David E Swayne; Colleen Thomas; Marie-Anne Rameix-Welti; Nadia Naffakh; Christine Warnes; Melanie Altholtz; Ruben Donis; Kanta Subbarao
Journal:  J Virol       Date:  2009-02-18       Impact factor: 5.103
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  16 in total

1.  An R195K Mutation in the PA-X Protein Increases the Virulence and Transmission of Influenza A Virus in Mammalian Hosts.

Authors:  Yipeng Sun; Zhe Hu; Xuxiao Zhang; Mingyue Chen; Zhen Wang; Guanlong Xu; Yuhai Bi; Qi Tong; Mingyang Wang; Honglei Sun; Juan Pu; Munir Iqbal; Jinhua Liu
Journal:  J Virol       Date:  2020-05-18       Impact factor: 5.103

Review 2.  Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic.

Authors:  William J Liu; Haixia Xiao; Lianpan Dai; Di Liu; Jianjun Chen; Xiaopeng Qi; Yuhai Bi; Yi Shi; George F Gao; Yingxia Liu
Journal:  Front Med       Date:  2021-04-16       Impact factor: 4.592

3.  Proteome Response of Chicken Embryo Fibroblast Cells to Recombinant H5N1 Avian Influenza Viruses with Different Neuraminidase Stalk Lengths.

Authors:  Yongtao Li; Fan Ming; Huimin Huang; Kelei Guo; Huanchun Chen; Meilin Jin; Hongbo Zhou
Journal:  Sci Rep       Date:  2017-01-12       Impact factor: 4.379

4.  Significantly elevated number of human infections with H7N9 virus in Jiangsu in eastern China, October 2016 to January 2017.

Authors:  Xiang Huo; Liling Chen; Xian Qi; Haodi Huang; Qigang Dai; Huiyan Yu; Yu Xia; Wendong Liu; Ke Xu; Wang Ma; Jun Zhang; Changjun Bao
Journal:  Euro Surveill       Date:  2017-03-30

Review 5.  Evolution and Adaptation of the Avian H7N9 Virus into the Human Host.

Authors:  Andrew T Bisset; Gerard F Hoyne
Journal:  Microorganisms       Date:  2020-05-21

Review 6.  Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry.

Authors:  Ruikun Du; Qinghua Cui; Lijun Rong
Journal:  Viruses       Date:  2019-05-20       Impact factor: 5.048

7.  Generation and protective efficacy of a cold-adapted attenuated avian H9N2 influenza vaccine.

Authors:  Yandi Wei; Lu Qi; Huijie Gao; Honglei Sun; Juan Pu; Yipeng Sun; Jinhua Liu
Journal:  Sci Rep       Date:  2016-07-26       Impact factor: 4.379

8.  Adaptive mutations of neuraminidase stalk truncation and deglycosylation confer enhanced pathogenicity of influenza A viruses.

Authors:  Sehee Park; Jin Il Kim; Ilseob Lee; Joon-Yong Bae; Kirim Yoo; Misun Nam; Juwon Kim; Mee Sook Park; Ki-Joon Song; Jin-Won Song; Sun-Ho Kee; Man-Seong Park
Journal:  Sci Rep       Date:  2017-09-07       Impact factor: 4.379

9.  Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016.

Authors:  Liping Ma; Tao Jin; Hanzhong Wang; Haizhou Liu; Runkun Wang; Yong Li; Guoxiang Yang; Yanping Xiong; Jing Chen; Jun Zhang; Guang Chen; Wei Li; Di Liu; Peng Lin; Yueying Huang; George F Gao; Quanjiao Chen
Journal:  Emerg Microbes Infect       Date:  2018-02-07       Impact factor: 7.163

10.  A Single Amino Acid in the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses.

Authors:  Joon-Yong Bae; Ilseob Lee; Jin Il Kim; Sehee Park; Kirim Yoo; Miso Park; Gayeong Kim; Mee Sook Park; Joo-Yeon Lee; Chun Kang; Kisoon Kim; Man-Seong Park
Journal:  J Virol       Date:  2018-06-13       Impact factor: 5.103
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