PURPOSE: We aimed to evaluate the effectiveness of diffusion-weighted magnetic resonance imaging (DW-MRI) and apparent diffusion coefficient (ADC) values in the diagnosis of acute appendicitis and differentiation of perforated and nonperforated appendicitis cases, with histopathologic correlation. MATERIALS AND METHODS: Sixty consecutive patients (34 males, 26 females; mean age, 35.6±15.5 years; range, 17-83 years) with a presumptive diagnosis of acute appendicitis were included in this prospective study. With a 1.5 Tesla MRI unit, DW-MRI examinations were performed with b values of 50, 400, and 800 s/mm(2). The mean ADC values of case and control groups, as well as in perforated and nonperforated groups were compared. RESULTS: Of the 60 cases, 44 had a radiological diagnosis of acute appendicitis, and 16 were regarded as normal. Of the 40 patients who underwent surgical operation, 12 had a histopathological diagnosis of perforated appendicitis, and 28 had nonperforated appendicitis. Mean ADC value in patients with acute appendicitis (1.01±0.26×10(-3) mm(2)/s) was lower than the control group (1.85±0.13×10(-3) mm(2)/s) (P < 0.001). Mean ADC value of the perforated group (0.79±0.19×10(-3) mm(2)/s) was lower than the nonperforated group (1.11±0.22×10(-3) mm(2)/s) (P < 0.001). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rate of DW-MRI in the diagnosis of acute appendicitis were 97.5%, 100%, 97.5%, 100%, and 98.1%, respectively. CONCLUSION: DW-MRI and ADC quantification are effective in the diagnosis of acute appendicitis, both in perforated and nonperforated cases.
PURPOSE: We aimed to evaluate the effectiveness of diffusion-weighted magnetic resonance imaging (DW-MRI) and apparent diffusion coefficient (ADC) values in the diagnosis of acute appendicitis and differentiation of perforated and nonperforated appendicitis cases, with histopathologic correlation. MATERIALS AND METHODS: Sixty consecutive patients (34 males, 26 females; mean age, 35.6±15.5 years; range, 17-83 years) with a presumptive diagnosis of acute appendicitis were included in this prospective study. With a 1.5 Tesla MRI unit, DW-MRI examinations were performed with b values of 50, 400, and 800 s/mm(2). The mean ADC values of case and control groups, as well as in perforated and nonperforated groups were compared. RESULTS: Of the 60 cases, 44 had a radiological diagnosis of acute appendicitis, and 16 were regarded as normal. Of the 40 patients who underwent surgical operation, 12 had a histopathological diagnosis of perforated appendicitis, and 28 had nonperforated appendicitis. Mean ADC value in patients with acute appendicitis (1.01±0.26×10(-3) mm(2)/s) was lower than the control group (1.85±0.13×10(-3) mm(2)/s) (P < 0.001). Mean ADC value of the perforated group (0.79±0.19×10(-3) mm(2)/s) was lower than the nonperforated group (1.11±0.22×10(-3) mm(2)/s) (P < 0.001). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rate of DW-MRI in the diagnosis of acute appendicitis were 97.5%, 100%, 97.5%, 100%, and 98.1%, respectively. CONCLUSION: DW-MRI and ADC quantification are effective in the diagnosis of acute appendicitis, both in perforated and nonperforated cases.
Authors: Marjolein M N Leeuwenburgh; Sebastiaan Jensch; Jan W C Gratama; Aart Spilt; Bart M Wiarda; H Wouter Van Es; Lodewijk P J Cobben; Patrick M M Bossuyt; Marja A Boermeester; Jaap Stoker Journal: Eur Radiol Date: 2013-09-08 Impact factor: 5.315
Authors: Michael D Repplinger; Joseph F Levy; Erica Peethumnongsin; Megan E Gussick; James E Svenson; Sean K Golden; William J Ehlenbach; Ryan P Westergaard; Scott B Reeder; David J Vanness Journal: J Magn Reson Imaging Date: 2015-12-22 Impact factor: 4.813
Authors: Michael D Repplinger; Perry J Pickhardt; Jessica B Robbins; Douglas R Kitchin; Tim J Ziemlewicz; Scott J Hetzel; Sean K Golden; John B Harringa; Scott B Reeder Journal: Radiology Date: 2018-04-24 Impact factor: 11.105