| Literature DB >> 23266572 |
N M Bougen1, N Amiry, Y Yuan, X J Kong, V Pandey, L J P Vidal, J K Perry, T Zhu, P E Lobie.
Abstract
Metastasis is the primary mediator of prostate cancer (PCA) lethality and poses a significant clinical obstacle. The identification of factors involved in the metastasis of PCA is imperative. We demonstrate herein that trefoil factor 1 (TFF1) promotes PCA cell migration and invasion in vitro and metastasis in vivo. The capacity of TFF1 to enhance cell migration/invasion is mediated by transcriptional repression of E-CADHERIN. Consideration of targeted inhibition of TFF1 to prevent metastasis of prostate carcinoma is warranted.Entities:
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Year: 2012 PMID： 23266572 DOI： 10.1016/j.canlet.2012.12.012
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679