Allene aziridination generates useful bicyclic methylene aziridine scaffolds that can be flexibly transformed into a range of stereochemically complex and densely functionalized amine-containing stereotriads. The scope of this chemistry has been limited by the poor chemoselectivity that often results when typical dinuclear Rh(II) catalysts are employed with homoallenic carbamates. Herein, Ag(I) catalysts that significantly improve the scope and yield of bicyclic methylene aziridines that can be prepared via allene aziridination are described.
Allene aziridination generates useful n class="Chemical">bicyclic methylene aziridine scaffolds that can be flexibly transformed into a range of stereochemically complex and densely functionalized amine-containing stereotriads. The scope of this chemistry has been limited by the poor chemoselectivity that often results when typical dinuclear Rh(II) catalysts are employed with homoallenic carbamates. Herein, Ag(I) catalysts that significantly improve the scope and yield of bicyclic methylene aziridines that can be prepared via allene aziridination are described.
Authors: Minxue Huang; Tzuhsiung Yang; Jonathan D Paretsky; John F Berry; Jennifer M Schomaker Journal: J Am Chem Soc Date: 2017-11-20 Impact factor: 15.419
Authors: Kate A Nicastri; Soren Zappia; Jared C Pratt; Julia M Duncan; Ilia A Guzei; Israel Fernández; Jennifer M Schomaker Journal: ACS Catal Date: 2022-01-11 Impact factor: 13.084
Authors: Jared W Rigoli; Cale D Weatherly; Juliet M Alderson; Brian T Vo; Jennifer M Schomaker Journal: J Am Chem Soc Date: 2013-11-11 Impact factor: 15.419