| Literature DB >> 23265271 |
Jessica L Klockow1, Timothy E Glass.
Abstract
Kynurenine, a metabolite of tryptophan, is known to contribute to cancer progression when overproduced. A method for facile fluorescent sensing of kynurenine using sensor 1 has been developed. When bound at low pH, sensor 1 undergoes a very large bathochromic shift because kynurenine extends the conjugation of the fluorophore. This unusual mechanism of activation provides a 390-fold fluorescence enhancement that is very specific to kynurenine and a wavelength of fluorescence that extends into the red.Entities:
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Year: 2012 PMID： 23265271 DOI： 10.1021/ol303025m
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005