BACKGROUND: Symptoms of depression and anxiety are common in patients with lung cancer and may produce an impact on both health-related quality of life (HRQL) and survival. The aim of the present study was to evaluate the association of depression and anxiety on HRQL, treatment adherence, and prognosis in patients with non-small cell lung cancer (NSCLC). METHODS: This is a prospective study of patients with stage IIIB or IV NSCLC. Depression and anxiety were measured using the hospital anxiety and depression scale, the International Neuropsychiatric Interview, and the HRQL with the EORTC QLQ-C30 and QLQ-LC13 questionnaires. Instruments were applied before treatment and repeated at 3 and 6 months. Lack of treatment adherence was considered as patients who stopped going to their consultation appointments. RESULTS: A total of 82 patients were included. At the initial evaluation, depression and anxiety were found in 32.9 and 34.1 % of patients, respectively. Depression was associated with feminine gender (p = 0.034) and poor performance status (p = 0.048). Depression and anxiety showed an association with HRQL. Patients with depression showed median overall survival of 6.8 months, whereas that for nondepressed patients was 14 months (hazard ratio [HR], 1.9; 95 % confidence interval (95 % CI), 1.03-3.7; p = 0.042). The 58 % of patients with depression had poor treatment adherence versus 42 % of patients without depression (p = 0.004). CONCLUSIONS: Depression and anxiety were present in one-third of patients with recently diagnosed NSCLC. Depression and anxiety were associated with decreased HRQL scales, and depression was independently associated with treatment adherence and with poor prognosis.
BACKGROUND: Symptoms of depression and anxiety are common in patients with lung cancer and may produce an impact on both health-related quality of life (HRQL) and survival. The aim of the present study was to evaluate the association of depression and anxiety on HRQL, treatment adherence, and prognosis in patients with non-small cell lung cancer (NSCLC). METHODS: This is a prospective study of patients with stage IIIB or IV NSCLC. Depression and anxiety were measured using the hospital anxiety and depression scale, the International Neuropsychiatric Interview, and the HRQL with the EORTC QLQ-C30 and QLQ-LC13 questionnaires. Instruments were applied before treatment and repeated at 3 and 6 months. Lack of treatment adherence was considered as patients who stopped going to their consultation appointments. RESULTS: A total of 82 patients were included. At the initial evaluation, depression and anxiety were found in 32.9 and 34.1 % of patients, respectively. Depression was associated with feminine gender (p = 0.034) and poor performance status (p = 0.048). Depression and anxiety showed an association with HRQL. Patients with depression showed median overall survival of 6.8 months, whereas that for nondepressed patients was 14 months (hazard ratio [HR], 1.9; 95 % confidence interval (95 % CI), 1.03-3.7; p = 0.042). The 58 % of patients with depression had poor treatment adherence versus 42 % of patients without depression (p = 0.004). CONCLUSIONS:Depression and anxiety were present in one-third of patients with recently diagnosed NSCLC. Depression and anxiety were associated with decreased HRQL scales, and depression was independently associated with treatment adherence and with poor prognosis.
Authors: Jacob E Berchuck; Craig S Meyer; Ning Zhang; Caroline M Berchuck; Neil N Trivedi; Beth Cohen; Sunny Wang Journal: JAMA Oncol Date: 2020-07-01 Impact factor: 31.777
Authors: Hoyee H Cheng; Thomas W Kamarck; Peter J Gianaros; Kathryn A Roecklein; Yanet Vanegas; Allan Tsung; David A Geller; James W Marsh; Nadia S Ahmed; Jennifer L Steel Journal: Psychooncology Date: 2019-06-18 Impact factor: 3.894
Authors: Jamile A Ashmore; Kirk W Ditterich; Claire C Conley; Melissa R Wright; Peggy S Howland; Kelly L Huggins; Jena Cooreman; Priscilla S Andrews; Donald R Nicholas; Lind Roberts; Larissa Hewitt; Joan N Scales; Jenny K Delap; Christine A Gray; Lynelle A Tyler; Charlotte Collins; Catherine M Whiting; Brittany M Brothers; Marlena M Ryba; Barbara L Andersen Journal: Am Psychol Date: 2018-07-19
Authors: Adrienne Beck; Ann H Cottingham; Patrick V Stutz; Rachel Gruber; Jennifer K Bernat; Paul R Helft; Laura Wilhelm; Karen Schmidt; Madison E Stout; Claire Willard; Shelley A Johns Journal: Palliat Support Care Date: 2018-07-24
Authors: Jenny G Turcott; María Del Rocío Guillen Núñez; Diana Flores-Estrada; Luis F Oñate-Ocaña; Zyanya Lucia Zatarain-Barrón; Feliciano Barrón; Oscar Arrieta Journal: Support Care Cancer Date: 2018-03-17 Impact factor: 3.603
Authors: Jie Lin; Katherine A McGlynn; Corey A Carter; Joel A Nations; William F Anderson; Craig D Shriver; Kangmin Zhu Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-08-26 Impact factor: 4.254