OBJECTIVE: Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF with cognitive impairment in T2DM has not been investigated. MATERIALS AND METHODS: We compared 208 patients with T2DM to 212 normal controls on serum BDNF and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). RESULTS: Serum BDNF levels were significantly decreased in T2DM patients compared to normal controls (p < 0.001). The total score and nearly all indexes (all p < 0.01) except for attention and visuospatial/constructional indexes (all p > 0.05) of RBANS were markedly lower in T2DM than controls. There was a positive relationship between serum BDNF and delayed memory in patients with T2DM. CONCLUSION: Our results suggest that BDNF may play a role in the pathophysiology of cognitive deficits, especially delayed memory in T2DM.
OBJECTIVE: Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF with cognitive impairment in T2DM has not been investigated. MATERIALS AND METHODS: We compared 208 patients with T2DM to 212 normal controls on serum BDNF and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). RESULTS: Serum BDNF levels were significantly decreased in T2DM patients compared to normal controls (p < 0.001). The total score and nearly all indexes (all p < 0.01) except for attention and visuospatial/constructional indexes (all p > 0.05) of RBANS were markedly lower in T2DM than controls. There was a positive relationship between serum BDNF and delayed memory in patients with T2DM. CONCLUSION: Our results suggest that BDNF may play a role in the pathophysiology of cognitive deficits, especially delayed memory in T2DM.
Authors: Zoe Arvanitakis; Robert Smith Wilson; Yan Li; Neelum Thanik Aggarwal; David Alan Bennett Journal: Diabetes Care Date: 2006-03 Impact factor: 19.112
Authors: Maria J Diógenes; Ana R Costenla; Luísa V Lopes; André Jerónimo-Santos; Vasco C Sousa; Bruno M Fontinha; Joaquim A Ribeiro; Ana M Sebastião Journal: Neuropsychopharmacology Date: 2011-04-27 Impact factor: 7.853
Authors: Seth A Margolis; Malka Zughaft Sears; Lori A Daiello; Carly Solon; Luba Nakhutina; Claire J Hoogendoorn; Jeffrey S Gonzalez Journal: Int J Geriatr Psychiatry Date: 2019-07-22 Impact factor: 3.485