BACKGROUND: Gender differences between donor and recipient might have an impact on the outcome after heart transplantation (HT). Data of more than 67,000 patients registered at the International Society of Heart Lung Transplantation (ISHLT) were reviewed focusing on the influence of gender differences on short- and long-term outcome after HT. METHODS: We performed a retrospective analysis of 67,855 cardiac allograft recipients. They received orthotopic HT between January 1, 1980 and June 30, 2009. In contrast to other studies the data for gender differences (donor gender and recipient gender) were calculated with respect to actuarial and conditional survival (without 30-day mortality). RESULTS: One-year survival was highest in male recipients of male donor hearts (mR/mD: 83.74%). The lowest 1-year outcome showed male recipients of female donor organs (mR/fD: 78.95%). Best 5-year survival rates were shown by male recipients with male donor organs (70.75%, p < 0.0001). These differences disappeared in survival conditional to 1 year, indicating that gender predominantly influences short-term outcome. CONCLUSIONS: The combination male recipient/female donor carries a higher risk for early mortality, whereas female recipients/male donor reveals favorable short-term results. Gender-matched HT would be ideal, but not suitable in practice because of the shortage of organs. Georg Thieme Verlag KG Stuttgart · New York.
BACKGROUND: Gender differences between donor and recipient might have an impact on the outcome after heart transplantation (HT). Data of more than 67,000 patients registered at the International Society of Heart Lung Transplantation (ISHLT) were reviewed focusing on the influence of gender differences on short- and long-term outcome after HT. METHODS: We performed a retrospective analysis of 67,855 cardiac allograft recipients. They received orthotopic HT between January 1, 1980 and June 30, 2009. In contrast to other studies the data for gender differences (donor gender and recipient gender) were calculated with respect to actuarial and conditional survival (without 30-day mortality). RESULTS: One-year survival was highest in male recipients of male donor hearts (mR/mD: 83.74%). The lowest 1-year outcome showed male recipients of female donor organs (mR/fD: 78.95%). Best 5-year survival rates were shown by male recipients with male donor organs (70.75%, p < 0.0001). These differences disappeared in survival conditional to 1 year, indicating that gender predominantly influences short-term outcome. CONCLUSIONS: The combination male recipient/female donor carries a higher risk for early mortality, whereas female recipients/male donor reveals favorable short-term results. Gender-matched HT would be ideal, but not suitable in practice because of the shortage of organs. Georg Thieme Verlag KG Stuttgart · New York.
Authors: María Dolores García-Cosío; Francisco González-Vilchez; Raquel López-Vilella; Eduardo Barge-Caballero; Manuel Gómez Bueno; Manuel Martínez-Selles; Jose María Arizón; Diego Rangel Sousa; José González-Costello; Sonia Mirabet; Félix Pérez-Villa; Beatriz Díaz Molina; Gregorio Rábago; Ana Portolés Ocampo; Luis de la Fuente Galán; Iris Garrido; Juan F Delgado Journal: Front Cardiovasc Med Date: 2021-02-25
Authors: Francesca Puoti; Andrea Ricci; Alessandro Nanni-Costa; Walter Ricciardi; Walter Malorni; Elena Ortona Journal: Biol Sex Differ Date: 2016-07-28 Impact factor: 5.027
Authors: He-Ming Chen; Zhong-Kai Hu; Xiao-Lin Zheng; Zhao-Shun Yuan; Zhao-Bin Xu; Ling-Qing Yuan; Vinicio A De Jesus Perez; Ke Yuan; Mark Orcholski; Xiao-Bo Liao Journal: Interact J Med Res Date: 2013-11-21