Literature DB >> 23249563

ATRX: the case of a peculiar chromatin remodeler.

Kajan Ratnakumar1, Emily Bernstein.   

Abstract

The SWI/SNF-like chromatin remodeler ATRX has recently garnered renewed attention. ATRX mutations were first identified in patients bearing the syndrome after which it is named, alpha thalassemia/mental retardation, X-linked. While ATRX has long been implicated in transcriptional regulation through multiple mechanisms, recent studies have identified a role for ATRX in the regulation of histone variant deposition. In addition, current reports describe ATRX to be mutated at high percentages in multiple tumor types, suggestive of a potential 'driver' role in cancer. Here we discuss the numerous and seemingly diverse roles for ATRX in transcriptional regulation and histone deposition and suggest that ATRX's effects are mediated by its regulation of histones within the chromatin template.

Entities:  

Keywords:  ATRX; histone variants; macroH2A and H3.3; telomeres; α-globin

Mesh：

Substances：

Year:  2012        PMID： 23249563      PMCID： PMC3549878          DOI： 10.4161/epi.23271

Source DB:  PubMed          Journal:  Epigenetics        ISSN： 1559-2294            Impact factor:   4.528


  56 in total

1.  Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.

Authors:  U Aapola; K Kawasaki; H S Scott; J Ollila; M Vihinen; M Heino; A Shintani; K Kawasaki; S Minoshima; K Krohn; S E Antonarakis; N Shimizu; J Kudoh; P Peterson
Journal:  Genomics       Date:  2000-05-01       Impact factor: 5.736

Review 2.  Chromatin insulators and boundaries: effects on transcription and nuclear organization.

Authors:  T I Gerasimova; V G Corces
Journal:  Annu Rev Genet       Date:  2001       Impact factor: 16.830

3.  Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS).

Authors:  Richard J Gibbons; Andrea Pellagatti; David Garrick; William G Wood; Nicola Malik; Helena Ayyub; Cordelia Langford; Jacqueline Boultwood; James S Wainscoat; Douglas R Higgs
Journal:  Nat Genet       Date:  2003-08       Impact factor: 38.330

4.  The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.

Authors:  Yutong Xue; Richard Gibbons; Zhijiang Yan; Dafeng Yang; Tarra L McDowell; Salvatore Sechi; Jun Qin; Sharleen Zhou; Doug Higgs; Weidong Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-02       Impact factor: 11.205

5.  Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation.

Authors:  R J Gibbons; T L McDowell; S Raman; D M O'Rourke; D Garrick; H Ayyub; D R Higgs
Journal:  Nat Genet       Date:  2000-04       Impact factor: 38.330

6.  Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes.

Authors:  T L McDowell; R J Gibbons; H Sutherland; D M O'Rourke; W A Bickmore; A Pombo; H Turley; K Gatter; D J Picketts; V J Buckle; L Chapman; D Rhodes; D R Higgs
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-23       Impact factor: 11.205

7.  Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association.

Authors:  N G Bérubé; C A Smeenk; D J Picketts
Journal:  Hum Mol Genet       Date:  2000-03-01       Impact factor: 6.150

8.  Acquired somatic ATRX mutations in myelodysplastic syndrome associated with alpha thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations.

Authors:  David P Steensma; Douglas R Higgs; Chris A Fisher; Richard J Gibbons
Journal:  Blood       Date:  2003-10-30       Impact factor: 22.113

9.  A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.

Authors:  Jun Tang; Shaobo Wu; Hongtu Liu; Rachael Stratt; Orr G Barak; Ramin Shiekhattar; David J Picketts; Xiaolu Yang
Journal:  J Biol Chem       Date:  2004-02-27       Impact factor: 5.157

10.  Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.

Authors:  Hideaki Tagami; Dominique Ray-Gallet; Geneviève Almouzni; Yoshihiro Nakatani
Journal:  Cell       Date:  2004-01-09       Impact factor: 41.582
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  35 in total

Review 1.  Histone variants: emerging players in cancer biology.

Authors:  Chiara Vardabasso; Dan Hasson; Kajan Ratnakumar; Chi-Yeh Chung; Luis F Duarte; Emily Bernstein
Journal:  Cell Mol Life Sci       Date:  2013-05-08       Impact factor: 9.261

2.  ATRX directs binding of PRC2 to Xist RNA and Polycomb targets.

Authors:  Kavitha Sarma; Catherine Cifuentes-Rojas; Ayla Ergun; Amanda Del Rosario; Yesu Jeon; Forest White; Ruslan Sadreyev; Jeannie T Lee
Journal:  Cell       Date:  2014-11-06       Impact factor: 41.582

3.  Metastatic malignant PEComa of the leg with identification of ATRX mutation by next-generation sequencing.

Authors:  Hussein Alnajar; Arlen Brickman; Lela Buckingham; Leonidas D Arvanitis
Journal:  Virchows Arch       Date:  2017-07-28       Impact factor: 4.064

Review 4.  The tale of a tail: histone H4 acetylation and the repair of DNA breaks.

Authors:  Surbhi Dhar; Ozge Gursoy-Yuzugullu; Ramya Parasuram; Brendan D Price
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2017-10-05       Impact factor: 6.237

5.  Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families.

Authors:  Jun Li; Hongyan Li; Igor Makunin; Bryony A Thompson; Kayoko Tao; Erin L Young; Jacqueline Lopez; Nicola J Camp; Sean V Tavtigian; Esther M John; Irene L Andrulis; Kum Kum Khanna; David Goldgar; Georgia Chenevix-Trench
Journal:  Breast Cancer Res Treat       Date:  2017-08-24       Impact factor: 4.872

6.  Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells.

Authors:  Mahesh Ramamoorthy; Susan Smith
Journal:  Cancer Cell       Date:  2015-09-14       Impact factor: 31.743

7.  Inherited germline ATRX mutation in two brothers with ATR-X syndrome and osteosarcoma.

Authors:  Jianling Ji; Catherine Quindipan; David Parham; Lishuang Shen; David Ruble; Moiz Bootwalla; Dennis T Maglinte; Xiaowu Gai; Sulagna C Saitta; Jaclyn A Biegel; Leo Mascarenhas
Journal:  Am J Med Genet A       Date:  2017-03-28       Impact factor: 2.802

8.  Genomic and transcriptomic characterisation of undifferentiated pleomorphic sarcoma of bone.

Authors:  Naser M Ali; Stefania Niada; Anna T Brini; Mark R Morris; Sathishkumar Kurusamy; Abdullah Alholle; David Huen; Cristina R Antonescu; Franck Tirode; Vaiyapuri Sumathi; Farida Latif
Journal:  J Pathol       Date:  2018-12-27       Impact factor: 7.996

9.  Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas.

Authors:  Sriram Venneti; Michelle Madden Felicella; Thomas Coyne; Joanna J Phillips; Daniel Gorovets; Jason T Huse; Julia Kofler; Chao Lu; Tarik Tihan; Lisa M Sullivan; Mariarita Santi; Alexander R Judkins; Arie Perry; Craig B Thompson
Journal:  J Neuropathol Exp Neurol       Date:  2013-04       Impact factor: 3.685

Review 10.  Sex, epilepsy, and epigenetics.

Authors:  Irfan A Qureshi; Mark F Mehler
Journal:  Neurobiol Dis       Date:  2014-07-04       Impact factor: 5.996
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