OBJECTIVE: The purpose of this study was to estimate the impact of interpregnancy weight change from first to second pregnancies in obese women on the risk of large-for-gestational-age (LGA) and small-for-gestational-age (SGA) infants. STUDY DESIGN: A population-based historical cohort analysis of 10,444 obese women in Missouri who delivered their first 2 singleton live infants from 1998-2005. Interpregnancy weight change was calculated as the difference between prepregnancy body mass index (BMI) of the first and second pregnancies. LGA and SGA births were compared among 3 interpregnancy weight change groups: (1) weight loss (≥2 BMI units), (2) weight gain (≥2 BMI units), and (3) reference group (BMI maintained within 2 units). Adjusted odds ratios (aOR) were calculated for LGA and SGA births with the use of multiple logistic regression. A dose-response relationship was assessed with a linear-by-linear χ(2) test. RESULTS: Compared with the reference group, interpregnancy weight loss was associated with lower risk of an LGA infant (aOR, 0.61; 95% confidence interval, 0.52-0.73), whereas interpregnancy weight gain was associated with increased risk of an LGA infant (aOR, 1.37; 95% confidence interval, 1.21-1.54). Interpregnancy BMI change was not related to SGA infant risk, except for weight loss of >8 BMI units. A significant dose-response relationship was observed for LGA infant risk (P < .001), but not SGA infant risk (P = .840). CONCLUSION: Mild-to-moderate interpregnancy weight loss in obese women reduced the risk of subsequent birth of LGA infants without increasing the risk of SGA infants. The interpregnancy interval may be a crucial period for targeting weight loss in obese women.
OBJECTIVE: The purpose of this study was to estimate the impact of interpregnancy weight change from first to second pregnancies in obesewomen on the risk of large-for-gestational-age (LGA) and small-for-gestational-age (SGA) infants. STUDY DESIGN: A population-based historical cohort analysis of 10,444 obesewomen in Missouri who delivered their first 2 singleton live infants from 1998-2005. Interpregnancy weight change was calculated as the difference between prepregnancy body mass index (BMI) of the first and second pregnancies. LGA and SGA births were compared among 3 interpregnancy weight change groups: (1) weight loss (≥2 BMI units), (2) weight gain (≥2 BMI units), and (3) reference group (BMI maintained within 2 units). Adjusted odds ratios (aOR) were calculated for LGA and SGA births with the use of multiple logistic regression. A dose-response relationship was assessed with a linear-by-linear χ(2) test. RESULTS: Compared with the reference group, interpregnancy weight loss was associated with lower risk of an LGA infant (aOR, 0.61; 95% confidence interval, 0.52-0.73), whereas interpregnancy weight gain was associated with increased risk of an LGA infant (aOR, 1.37; 95% confidence interval, 1.21-1.54). Interpregnancy BMI change was not related to SGA infant risk, except for weight loss of >8 BMI units. A significant dose-response relationship was observed for LGA infant risk (P < .001), but not SGA infant risk (P = .840). CONCLUSION: Mild-to-moderate interpregnancy weight loss in obesewomen reduced the risk of subsequent birth of LGA infants without increasing the risk of SGA infants. The interpregnancy interval may be a crucial period for targeting weight loss in obesewomen.
Authors: M L Erickson; J T Mey; C L Axelrod; D Paul; L Gordesky; K Russell; H Barkoukis; P O'Tierney-Ginn; R A Fielding; J P Kirwan; P M Catalano Journal: Contemp Clin Trials Date: 2020-05-08 Impact factor: 2.226
Authors: Annie M Dude; Michelle A Kominiarek; David M Haas; Jay Iams; Brian M Mercer; Samuel Parry; Uma M Reddy; George Saade; Robert M Silver; Hyagriv Simhan; Ronald Wapner; Deborah Wing; William Grobman Journal: Pregnancy Hypertens Date: 2020-03-03 Impact factor: 2.899
Authors: Heidi Dutton; Sarah Jean Borengasser; Laura Marie Gaudet; Linda A Barbour; Erin Joanne Keely Journal: Med Clin North Am Date: 2018-01 Impact factor: 5.456
Authors: Camille A Robinson; Alison K Cohen; David H Rehkopf; Julianna Deardorff; Lorrene Ritchie; Ruvani T Jayaweera; Jeremy R Coyle; Barbara Abrams Journal: Prev Med Date: 2013-12-24 Impact factor: 4.018