Literature DB >> 23243460

Odyssey of a cancer nanoparticle: from injection site to site of action.

Joseph W Nichols1, You Han Bae.   

Abstract

No chemotherapeutic drug can be effective until it is delivered to its target site. Nano-sized drug carriers are designed to transport therapeutic or diagnostic materials from the point of administration to the drug's site of action. This task requires the nanoparticle carrying the drug to complete a journey from the injection site to the site of action. The journey begins with the injection of the drug carrier into the bloodstream and continues through stages of circulation, extravasation, accumulation, distribution, endocytosis, endosomal escape, intracellular localization and-finally-action. Effective nanoparticle design should consider all of these stages to maximize drug delivery to the entire tumor and effectiveness of the treatment.

Entities:  

Year:  2012        PMID： 23243460      PMCID： PMC3519442          DOI： 10.1016/j.nantod.2012.10.010

Source DB:  PubMed          Journal:  Nano Today        ISSN： 1748-0132            Impact factor:   20.722


  102 in total

Review 1.  Intracellular partitioning of cell organelles and extraneous nanoparticles during mitosis.

Authors:  Nathalie Symens; Stefaan J Soenen; Joanna Rejman; Kevin Braeckmans; Stefaan C De Smedt; Katrien Remaut
Journal:  Adv Drug Deliv Rev       Date:  2011-12-02       Impact factor: 15.470

2.  Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection.

Authors:  Zeyu Xiao; Etgar Levy-Nissenbaum; Frank Alexis; Andrej Lupták; Benjamin A Teply; Juliana M Chan; Jinjun Shi; Elise Digga; Judy Cheng; Robert Langer; Omid C Farokhzad
Journal:  ACS Nano       Date:  2012-01-03       Impact factor: 15.881

3.  Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.

Authors:  Triantafyllos Stylianopoulos; Ming-Zher Poh; Numpon Insin; Moungi G Bawendi; Dai Fukumura; Lance L Munn; Rakesh K Jain
Journal:  Biophys J       Date:  2010-09-08       Impact factor: 4.033

4.  Ultrasound-guided intratumoral administration of collagenase-2 improved liposome drug accumulation in solid tumor xenografts.

Authors:  Xiangpeng Zheng; Beth A Goins; Ivan L Cameron; Cristina Santoyo; Ande Bao; Victoria C Frohlich; Gary D Fullerton
Journal:  Cancer Chemother Pharmacol       Date:  2010-03-21       Impact factor: 3.333

Review 5.  Targeting tumors using estrogen receptor ligand conjugates.

Authors:  N O Keely; M J Meegan
Journal:  Curr Cancer Drug Targets       Date:  2009-05       Impact factor: 3.428

6.  Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

Authors:  Y Boucher; L T Baxter; R K Jain
Journal:  Cancer Res       Date:  1990-08-01       Impact factor: 12.701

7.  The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.

Authors:  Junko Ozao-Choy; Ge Ma; Johnny Kao; George X Wang; Marcia Meseck; Max Sung; Myron Schwartz; Celia M Divino; Ping-Ying Pan; Shu-Hsia Chen
Journal:  Cancer Res       Date:  2009-03-10       Impact factor: 12.701

8.  Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer.

Authors:  M E R O'Brien; N Wigler; M Inbar; R Rosso; E Grischke; A Santoro; R Catane; D G Kieback; P Tomczak; S P Ackland; F Orlandi; L Mellars; L Alland; C Tendler
Journal:  Ann Oncol       Date:  2004-03       Impact factor: 32.976

9.  Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

Authors:  Y Boucher; R K Jain
Journal:  Cancer Res       Date:  1992-09-15       Impact factor: 12.701

10.  Does a targeting ligand influence nanoparticle tumor localization or uptake?

Authors:  Kathleen F Pirollo; Esther H Chang
Journal:  Trends Biotechnol       Date:  2008-08-21       Impact factor: 19.536
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  76 in total

Review 1.  Polymeric Nanostructures for Imaging and Therapy.

Authors:  Mahmoud Elsabahy; Gyu Seong Heo; Soon-Mi Lim; Guorong Sun; Karen L Wooley
Journal:  Chem Rev       Date:  2015-08-04       Impact factor: 60.622

Review 2.  Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics.

Authors:  Minseok Suh; Dong Soo Lee
Journal:  Nucl Med Mol Imaging       Date:  2018-11-09

3.  The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors.

Authors:  Mukaddes Izci; Christy Maksoudian; Bella B Manshian; Stefaan J Soenen
Journal:  Chem Rev       Date:  2021-01-14       Impact factor: 60.622

4.  Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles.

Authors:  Christopher G England; M Clarke Miller; Ashani Kuttan; John O Trent; Hermann B Frieboes
Journal:  Eur J Pharm Biopharm       Date:  2015-03-07       Impact factor: 5.571

Review 5.  Nanocarrier-Based Therapeutics and Theranostics Drug Delivery Systems for Next Generation of Liver Cancer Nanodrug Modalities.

Authors:  Umme Ruman; Sharida Fakurazi; Mas Jaffri Masarudin; Mohd Zobir Hussein
Journal:  Int J Nanomedicine       Date:  2020-03-03

Review 6.  Exploiting homing abilities of cell carriers: Targeted delivery of nanoparticles for cancer therapy.

Authors:  Pamela Tiet; Jacob M Berlin
Journal:  Biochem Pharmacol       Date:  2017-09-21       Impact factor: 5.858

Review 7.  Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment.

Authors:  Yunlu Dai; Can Xu; Xiaolian Sun; Xiaoyuan Chen
Journal:  Chem Soc Rev       Date:  2017-05-18       Impact factor: 54.564

8.  Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes.

Authors:  Meredith A Jackson; Sean K Bedingfield; Fang Yu; Mitchell E Stokan; Rachel E Miles; Elizabeth J Curvino; Ella N Hoogenboezem; Rachel H Bonami; Shrusti S Patel; Peggy L Kendall; Todd D Giorgio; Craig L Duvall
Journal:  Biomaterials       Date:  2018-11-10       Impact factor: 12.479

9.  Dextran-functionalized magnetic fluid mediating magnetohyperthermia for treatment of Ehrlich-solid-tumor-bearing mice: toxicological and histopathological evaluations.

Authors:  Ana Luisa Miranda-Vilela; Kelly Reis Yamamoto; Kely Lopes Caiado Miranda; Breno Noronha Matos; Marcos Célio de Almeida; João Paulo Figueiró Longo; José de Souza Filho; Juliana Menezes Soares Fernandes; Patrícia Pommé Confessori Sartoratto; Zulmira Guerrero Marques Lacava
Journal:  Tumour Biol       Date:  2013-12-01

10.  Hepatocellular Carcinoma: Intra-arterial Delivery of Doxorubicin-loaded Hollow Gold Nanospheres for Photothermal Ablation-Chemoembolization Therapy in Rats.

Authors:  Junjie Li; Min Zhou; Fengyong Liu; Chiyi Xiong; Wanqin Wang; Qizhen Cao; Xiaoxia Wen; J David Robertson; Xin Ji; Y Andrew Wang; Sanjay Gupta; Chun Li
Journal:  Radiology       Date:  2016-06-27       Impact factor: 11.105
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