| Literature DB >> 23240782 |
Hiyoung Kim1, Jungwook Chin, Hyukjae Choi, Kyungryul Baek, Tae-Gu Lee, Seong Eon Park, Weihong Wang, Dongyup Hahn, Inho Yang, Jihye Lee, Bora Mun, Merrick Ekins, Sang-Jip Nam, Heonjoong Kang.
Abstract
Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC(50) of 23.7 nM.Entities:
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Year: 2012 PMID： 23240782 DOI： 10.1021/ol3031318
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005