"Classical" electropermeabilization modeling at the cell scale.

The aim of this paper is to provide new models of cell electropermeabilization involving only a few parameters. A static and a dynamical model, which are based on the description of the electric potential in a biological cell, are derived. Existence and uniqueness results are provided for each differential system, and an accurate numerical method to compute the solution is described. We then present numerical simulations that corroborate the experimental observations, providing the consistency of the modeling. We emphasize that our new models involve very few parameters, compared with the most achieved models of Neu and Krassowska (Phys Rev E 53(3):3471-3482, 1999) and DeBruin and Krassowska (Biophys J 77:1225-1233, 1999), but they provide the same qualitative results. Thus, these models will facilitate drastically the forthcoming inverse problem solving, which will consist in fitting them with the experiments.