| Literature DB >> 23238869 |
Sofie M Adriaanse1, Ernesto J Sanz-Arigita, Maja A A Binnewijzend, Rik Ossenkoppele, Nelleke Tolboom, Daniëlle M E van Assema, Alle Meije Wink, Ronald Boellaard, Maqsood Yaqub, Albert D Windhorst, Wiesje M van der Flier, Philip Scheltens, Adriaan A Lammertsma, Serge A R B Rombouts, Frederik Barkhof, Bart N M van Berckel.
Abstract
The purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN.Entities:
Keywords: Alzheimer disease; amyloid; default mode network; magnetic resonance imaging; mild cognitive impairment; positron emission tomography; resting-state fMRI
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Year: 2012 PMID： 23238869 PMCID： PMC6869670 DOI： 10.1002/hbm.22213
Source DB: PubMed Journal: Hum Brain Mapp ISSN： 1065-9471 Impact factor: 5.038