OBJECTIVES: To evaluate the feasibility of diagnosing recurrence of HCC after TACE color-coded iodine CT (CICT) based on arterial phase scans obtained by a dual-energy CT (DECT) scanner. METHODS: A CICT scan was acquired from an iodine map after applying material decomposition of the liver tissue and setting a threshold attenuation level for viable tumors. Two radiologists reviewed both conventional and CICT sets in 31 patients who had a history of TACE for HCC. The performances in detecting local tumor progression (LTP) were evaluated by alternative free-response receiver operating characteristics. The rate of uncertain diagnosis and interobserver agreement of the diagnosis were explored. Additionally, the reading time and radiation dose were also investigated. RESULTS: The mean figures of merit of the conventional and CICT sets for LTP were 0.818 and 0.847, respectively (p=0.459). The rate of uncertain diagnosis was significantly decreased in CICT sets (34.5% vs. 0%), and interobserver agreement was improved (k=0.527 vs. 0.718). On the CICT set, mean reading time was reduced by 49s and mean radiation dose was also decreased by 18.3% when replacing the non-contrast CT with CICT. CONCLUSIONS: CICT is comparable to conventional liver CT protocol in demonstrating viable HCCs, while it allows a reduction in radiation dose.
OBJECTIVES: To evaluate the feasibility of diagnosing recurrence of HCC after TACE color-coded iodine CT (CICT) based on arterial phase scans obtained by a dual-energy CT (DECT) scanner. METHODS: A CICT scan was acquired from an iodine map after applying material decomposition of the liver tissue and setting a threshold attenuation level for viable tumors. Two radiologists reviewed both conventional and CICT sets in 31 patients who had a history of TACE for HCC. The performances in detecting local tumor progression (LTP) were evaluated by alternative free-response receiver operating characteristics. The rate of uncertain diagnosis and interobserver agreement of the diagnosis were explored. Additionally, the reading time and radiation dose were also investigated. RESULTS: The mean figures of merit of the conventional and CICT sets for LTP were 0.818 and 0.847, respectively (p=0.459). The rate of uncertain diagnosis was significantly decreased in CICT sets (34.5% vs. 0%), and interobserver agreement was improved (k=0.527 vs. 0.718). On the CICT set, mean reading time was reduced by 49s and mean radiation dose was also decreased by 18.3% when replacing the non-contrast CT with CICT. CONCLUSIONS: CICT is comparable to conventional liver CT protocol in demonstrating viable HCCs, while it allows a reduction in radiation dose.
Authors: K Hellbach; A Sterzik; W Sommer; M Karpitschka; N Hummel; J Casuscelli; M Ingrisch; M Schlemmer; A Graser; Michael Staehler Journal: Eur Radiol Date: 2016-09-27 Impact factor: 5.315
Authors: Wolfgang M Thaiss; Ulrike Haberland; Sascha Kaufmann; Daniel Spira; Christoph Thomas; Konstantin Nikolaou; Marius Horger; Alexander W Sauter Journal: Eur Radiol Date: 2015-12-17 Impact factor: 5.315
Authors: Anushri Parakh; Chansik An; Simon Lennartz; Prabhakar Rajiah; Benjamin M Yeh; Frank J Simeone; Dushyant V Sahani; Avinash R Kambadakone Journal: Radiographics Date: 2021-02-19 Impact factor: 5.333