Literature DB >> 2323828

Diminished immunogenicity of a recombination-deficient derivative of Vibrio cholerae vaccine strain CVD103.

J M Ketley1, J B Kaper, D A Herrington, G Losonsky, M M Levine.   

Abstract

To address potential concerns over the release of genetically engineered live bacterial vaccines, we constructed a recombination-deficient derivative of the Vibrio cholerae O1 vaccine strain CVD103 (CVD103RM). Oral immunization of adult volunteers with CVD103RM showed that the recA mutation significantly diminished colonization ability and immunogenicity of the vaccine strain.

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Year:  1990        PMID： 2323828      PMCID： PMC258653          DOI： 10.1128/iai.58.5.1481-1484.1990

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  28 in total

1.  cis-Dominant, transfer-deficient mutants of the Escherichia coli K-12 F sex factor.

Authors:  M S Guyer; A J Clark
Journal:  J Bacteriol       Date:  1976-01       Impact factor: 3.490

2.  Purified Escherichia coli recA protein catalyzes homologous pairing of superhelical DNA and single-stranded fragments.

Authors:  T Shibata; C DasGupta; R P Cunningham; C M Radding
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

3.  Duplication and amplification of toxin genes in Vibrio cholerae.

Authors:  J J Mekalanos
Journal:  Cell       Date:  1983-11       Impact factor: 41.582

4.  Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development.

Authors:  J J Mekalanos; D J Swartz; G D Pearson; N Harford; F Groyne; M de Wilde
Journal:  Nature       Date:  1983 Dec 8-14       Impact factor: 49.962

5.  Expression of Serratia marcescens extracellular proteins requires recA.

Authors:  T K Ball; C R Wasmuth; S C Braunagel; M J Benedik
Journal:  J Bacteriol       Date:  1990-01       Impact factor: 3.490

6.  Initiation of general recombination catalyzed in vitro by the recA protein of Escherichia coli.

Authors:  K McEntee; G M Weinstock; I R Lehman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

7.  Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans.

Authors:  D H Figurski; D R Helinski
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

8.  Magnitude, kinetics, and duration of vibriocidal antibody responses in North Americans after ingestion of Vibrio cholerae.

Authors:  M L Clements; M M Levine; C R Young; R E Black; Y L Lim; R M Robins-Browne; J P Craig
Journal:  J Infect Dis       Date:  1982-04       Impact factor: 5.226

9.  Recombinant DNA risk assessment studies in humans: efficacy of poorly mobilizable plasmids in biologic containment.

Authors:  M M Levine; J B Kaper; H Lockman; R E Black; M L Clements; S Falkow
Journal:  J Infect Dis       Date:  1983-10       Impact factor: 5.226

10.  Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. 2. Results of the serological surveys in the study population--the relationship of case rate to antibody titre and an estimate of the inapparent infection rate with Vibrio cholerae.

Authors:  W H Mosley; W M McCormack; A Ahmed; A K Chowdhury; R K Barui
Journal:  Bull World Health Organ       Date:  1969       Impact factor: 9.408
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  5 in total

1.  Construction and analysis of a Vibrio cholerae delta-aminolevulinic acid auxotroph which confers protective immunity in a rabbit model.

Authors:  S G Rijpkema; E M Bik; W H Jansen; H Gielen; L F Versluis; A H Stouthamer; P A Guinée; F R Mooi
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

2.  The OmpU outer membrane protein, a potential adherence factor of Vibrio cholerae.

Authors:  V Sperandio; J A Girón; W D Silveira; J B Kaper
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441

3.  Development and characterization of recA mutants of Campylobacter jejuni for inclusion in attenuated vaccines.

Authors:  P Guerry; P M Pope; D H Burr; J Leifer; S W Joseph; A L Bourgeois
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

4.  CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor.

Authors:  G D Pearson; A Woods; S L Chiang; J J Mekalanos
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

5.  Preliminary assessment of the safety and immunogenicity of a new CTXPhi-negative, hemagglutinin/protease-defective El Tor strain as a cholera vaccine candidate.

Authors:  J A Benítez; L García; A Silva; H García; R Fando; B Cedré; A Pérez; J Campos; B L Rodríguez; J L Pérez; T Valmaseda; O Pérez; A Pérez; M Ramírez; T Ledón; M D Jidy; M Lastre; L Bravo; G Sierra
Journal:  Infect Immun       Date:  1999-02       Impact factor: 3.441
  5 in total

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