Literature DB >> 6646234

Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development.

J J Mekalanos, D J Swartz, G D Pearson, N Harford, F Groyne, M de Wilde.   

Abstract

Nucleotide sequence and deletion analysis have been used to identify the regulatory and coding sequences comprising the cholera toxin operon (ctx). Incorporation of defined in vitro-generated ctx deletion mutations into Vibrio cholerae by in vivo genetic recombination produced strains which have practical value in cholera vaccine development.

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Year:  1983        PMID： 6646234     DOI： 10.1038/306551a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  243 in total

1.  Molecular cloning of an apoptosis-inducing protein, pierisin, from cabbage butterfly: possible involvement of ADP-ribosylation in its activity.

Authors:  M Watanabe; T Kono; Y Matsushima-Hibiya; T Kanazawa; N Nishisaka; T Kishimoto; K Koyama; T Sugimura; K Wakabayashi
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-14       Impact factor: 11.205

2.  Molecular characterization of a new ribotype of Vibrio cholerae O139 Bengal associated with an outbreak of cholera in Bangladesh.

Authors:  S M Faruque; A K Siddique; M N Saha; M M Rahman; K Zaman; M J Albert; D A Sack; R B Sack
Journal:  J Clin Microbiol       Date:  1999-05       Impact factor: 5.948

3.  Association of protease activity in Vibrio cholerae vaccine strains with decreases in transcellular epithelial resistance of polarized T84 intestinal epithelial cells.

Authors:  S F Mel; K J Fullner; S Wimer-Mackin; W I Lencer; J J Mekalanos
Journal:  Infect Immun       Date:  2000-11       Impact factor: 3.441

4.  Polar targeting of Shigella virulence factor IcsA in Enterobacteriacae and Vibrio.

Authors:  M Charles; M Pérez; J H Kobil; M B Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-31       Impact factor: 11.205

5.  Molecular analysis of toxigenic Vibrio cholerae O139 Bengal strains isolated in Bangladesh between 1993 and 1996: evidence for emergence of a new clone of the Bengal vibrios.

Authors:  S M Faruque; K M Ahmed; A K Siddique; K Zaman; A R Alim; M J Albert
Journal:  J Clin Microbiol       Date:  1997-09       Impact factor: 5.948

6.  Effects of amino acid supplementation on porin expression and ToxR levels in Vibrio cholerae.

Authors:  Alexandra R Mey; Stephanie A Craig; Shelley M Payne
Journal:  Infect Immun       Date:  2011-12-05       Impact factor: 3.441

7.  CTX prophages in classical biotype Vibrio cholerae: functional phage genes but dysfunctional phage genomes.

Authors:  B M Davis; K E Moyer; E F Boyd; M K Waldor
Journal:  J Bacteriol       Date:  2000-12       Impact factor: 3.490

8.  Chemiosmotic mechanism of antimicrobial activity of Ag(+) in Vibrio cholerae.

Authors:  Pavel Dibrov; Judith Dzioba; Khoosheh K Gosink; Claudia C Häse
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

9.  Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination.

Authors:  Tomonori Nochi; Hidenori Takagi; Yoshikazu Yuki; Lijun Yang; Takehiro Masumura; Mio Mejima; Ushio Nakanishi; Akiko Matsumura; Akihiro Uozumi; Takachika Hiroi; Shigeto Morita; Kunisuke Tanaka; Fumio Takaiwa; Hiroshi Kiyono
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-15       Impact factor: 11.205

10.  Induction of interleukin-8 in T84 cells by Vibrio cholerae.

Authors:  Xin Zhou; Da Q Gao; Jane Michalski; Jorge A Benitez; James B Kaper
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441
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