BACKGROUND: Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this. METHODS: We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data. RESULTS: We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response. CONCLUSIONS: These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.
BACKGROUND: Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this. METHODS: We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data. RESULTS: We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response. CONCLUSIONS: These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.
Authors: Laura M Hack; Gabriel R Fries; Harris A Eyre; Chad A Bousman; Ajeet B Singh; Joao Quevedo; Vineeth P John; Bernhard T Baune; Boadie W Dunlop Journal: J Affect Disord Date: 2019-02-06 Impact factor: 4.839
Authors: C Fabbri; C Crisafulli; D Gurwitz; J Stingl; R Calati; D Albani; G Forloni; M Calabrò; R Martines; S Kasper; J Zohar; A Juven-Wetzler; D Souery; S Montgomery; J Mendlewicz; G D Girolamo; A Serretti Journal: Pharmacogenomics J Date: 2015-04-07 Impact factor: 3.550