| Literature DB >> 23235143 |
Joe R Delaney1, Christopher Murakami, Annie Chou, Daniel Carr, Jennifer Schleit, George L Sutphin, Elroy H An, Anthony S Castanza, Marissa Fletcher, Sarani Goswami, Sean Higgins, Mollie Holmberg, Jessica Hui, Monika Jelic, Ki-Soo Jeong, Jin R Kim, Shannon Klum, Eric Liao, Michael S Lin, Winston Lo, Hillary Miller, Richard Moller, Zhao J Peng, Tom Pollard, Prarthana Pradeep, Dillon Pruett, Dilreet Rai, Vanessa Ros, Alex Schuster, Minnie Singh, Benjamin L Spector, Helen Vander Wende, Adrienne M Wang, Brian M Wasko, Brady Olsen, Matt Kaeberlein.
Abstract
Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary restriction during chronological aging delays the reduction in subsequent replicative life span up to at least 23days of chronological age. We further show that among the viable portion of the control population aged 26days, individual cells with the lowest mitochondrial membrane potential have the longest subsequent replicative lifespan. These observations demonstrate that dietary restriction modulates a common molecular mechanism linking chronological and replicative aging in yeast and indicate a critical role for mitochondrial function in this process.Entities:
Keywords: Caloric restriction; Calorie restriction; Chronological lifespan; Dietary restriction; Glucose; Mitochondria; Replicative lifespan
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Year: 2012 PMID： 23235143 PMCID： PMC3604125 DOI： 10.1016/j.exger.2012.12.001
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032