Literature DB >> 23233588

Does antithymocyte globulin have a place in reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation?

Tanya Siddiqi1, Didier Blaise.   

Abstract

A 63-year-old male patient without siblings is treated for acute myeloid leukemia with poor prognostic cytogenetics. Despite achieving a first complete remission, he relapsed within the first year of diagnosis. He then achieved a second complete remission. A search for an HLA-identical unrelated donor identified a 10/10 possible match. The patient has several comorbidities (hematopoietic stem cell comorbidity index = 3) and it is recommended that he undergo a reduced-intensity conditioning regimen for allogeneic peripheral blood stem cell transplantation. The patient is well-read on allogeneic stem cell transplantation and asks you the merits of antithymocyte globulin that you propose to include in the conditioning regimen.

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Year:  2012        PMID: 23233588     DOI: 10.1182/asheducation-2012.1.246

Source DB:  PubMed          Journal:  Hematology Am Soc Hematol Educ Program        ISSN: 1520-4383


  5 in total

Review 1.  Reduced-intensity conditioned allogeneic SCT in adults with AML.

Authors:  R Reshef; D L Porter
Journal:  Bone Marrow Transplant       Date:  2015-03-02       Impact factor: 5.483

2.  Idarubicin-intensified haploidentical HSCT with GvHD prophylaxis of ATG and basiliximab provides comparable results to sibling donors in high-risk acute leukemia.

Authors:  R Zhang; W Shi; H-F Wang; Y You; Z-D Zhong; W-M Li; C Zhang; X Lu; Y-D Wang; P Zheng; J Fang; M Hong; Q-L Wu; L-H Xia
Journal:  Bone Marrow Transplant       Date:  2017-06-05       Impact factor: 5.483

Review 3.  Indications and outcomes of reduced-toxicity hematopoietic stem cell transplantation in adult patients with hematological malignancies.

Authors:  S Fadilah Abdul Wahid
Journal:  Int J Hematol       Date:  2013-04-13       Impact factor: 2.490

4.  Risk factors for outcomes after unrelated cord blood transplantation for adults with acute lymphoblastic leukemia: a report on behalf of Eurocord and the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.

Authors:  L Tucunduva; A Ruggeri; G Sanz; S Furst; G Socié; M Michallet; W Arcese; N Milpied; I Yakoub-Agha; W Linkesch; J Cornelissen; L Mannone; A P Iori; J-M Ribera; J Sanz; P Montesinos; D Purtill; M Labopin; E Gluckman; M Mohty; V Rocha
Journal:  Bone Marrow Transplant       Date:  2014-07       Impact factor: 5.483

5.  Tools for the Precision Medicine Era: How to Develop Highly Personalized Treatment Recommendations From Cohort and Registry Data Using Q-Learning.

Authors:  Elizabeth F Krakow; Michael Hemmer; Tao Wang; Brent Logan; Mukta Arora; Stephen Spellman; Daniel Couriel; Amin Alousi; Joseph Pidala; Michael Last; Silvy Lachance; Erica E M Moodie
Journal:  Am J Epidemiol       Date:  2017-07-15       Impact factor: 4.897

  5 in total

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